Options
Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling
Date Issued
2016-10
Date Available
2019-04-23T08:49:37Z
Abstract
Eosinophils account for 1–3% of peripheral blood leukocytes and accumulate at sites of allergic inflammation, where they play a pathogenic role. Studies have shown that treatment with mepolizumab (an anti-IL-5 monoclonal antibody) is beneficial to patients with severe eosinophilic asthma, however, the mechanism of precisely how eosinophils mediate these pathogenic effects is uncertain. Eosinophils contain several cationic granule proteins, including Eosinophil Peroxidase (EPO). The main significance of this work is the discovery of EPO as a novel ligand for the HER2 receptor. Following HER2 activation, EPO induces activation of FAK and subsequent activation of β1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 and the HER2 receptor. These data identify a receptor for one of the eosinophil granule proteins and demonstrate a potential explanation of the proliferative effects of eosinophils.
Sponsorship
Health Research Board
Other Sponsorship
Wellcome Trust
Type of Material
Journal Article
Publisher
Elsevier
Journal
Clinical Immunology
Volume
171
Start Page
1
End Page
11
Copyright (Published Version)
2016 the Authors
Language
English
Status of Item
Peer reviewed
ISSN
1521-6616
This item is made available under a Creative Commons License
File(s)
Name
Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.pdf
Size
1.72 MB
Format
Owning collection
Scopus© citations
6
Acquisition Date
Apr 17, 2024
Apr 17, 2024
Views
839
Last Month
4
4
Acquisition Date
Apr 17, 2024
Apr 17, 2024
Downloads
261
Last Month
2
2
Acquisition Date
Apr 17, 2024
Apr 17, 2024