EpimiRBase: a comprehensive database of microRNA-epilepsy associations

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Title: EpimiRBase: a comprehensive database of microRNA-epilepsy associations
Authors: Mooney, Catherine
Becker, Brett A.
Raoof, Rana
Henshall, David C
Permanent link: http://hdl.handle.net/10197/10065
Date: 8-Jan-2016
Online since: 2019-04-23T08:54:58Z
Abstract: MicroRNAs are short non-coding RNA which function to fine-tune protein levels in all cells. This is achieved mainly by sequence-specific binding to 3′ untranslated regions of target mRNA. The result is post-transcriptional interference in gene expression which reduces protein levels either by promoting destabilisation of mRNA or translational repression. Research published since 2010 shows that microRNAs are important regulators of gene expression in epilepsy. A series of microRNA profiling studies in rodent and human tissue has revealed that epilepsy is associated with wide ranging changes to microRNA levels in the brain. These are thought to influence processes including cell death, inflammation and re-wiring of neuronal networks. MicroRNAs have also been identified in the blood after injury to the brain and therefore may serve as biomarkers of epilepsy. EpimiRBase is a manually curated database for researchers interested in the role of microRNAs in epilepsy. The fully searchable database includes information on up- and down-regulated microRNAs in the brain and blood, as well as functional studies, and covers both rodent models and human epilepsy.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Type of material: Journal Article
Publisher: Oxford University Press
Journal: Bioinformatics
Volume: 32
Issue: 9
Start page: 1436
End page: 1438
Copyright (published version): 2016 the Authors
Keywords: EpilepsyMicroRNAsRNAGene expression regulationBiomarkers of epilepsy
DOI: 10.1093/bioinformatics/btw008
Language: en
Status of Item: Peer reviewed
Appears in Collections:Computer Science Research Collection

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