EpimiRBase: a comprehensive database of microRNA-epilepsy associations
|Title:||EpimiRBase: a comprehensive database of microRNA-epilepsy associations||Authors:||Mooney, Catherine; Becker, Brett A.; Raoof, Rana; Henshall, David C||Permanent link:||http://hdl.handle.net/10197/10065||Date:||8-Jan-2016||Online since:||2019-04-23T08:54:58Z||Abstract:||MicroRNAs are short non-coding RNA which function to fine-tune protein levels in all cells. This is achieved mainly by sequence-specific binding to 3′ untranslated regions of target mRNA. The result is post-transcriptional interference in gene expression which reduces protein levels either by promoting destabilisation of mRNA or translational repression. Research published since 2010 shows that microRNAs are important regulators of gene expression in epilepsy. A series of microRNA profiling studies in rodent and human tissue has revealed that epilepsy is associated with wide ranging changes to microRNA levels in the brain. These are thought to influence processes including cell death, inflammation and re-wiring of neuronal networks. MicroRNAs have also been identified in the blood after injury to the brain and therefore may serve as biomarkers of epilepsy. EpimiRBase is a manually curated database for researchers interested in the role of microRNAs in epilepsy. The fully searchable database includes information on up- and down-regulated microRNAs in the brain and blood, as well as functional studies, and covers both rodent models and human epilepsy.||Funding Details:||European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
|Type of material:||Journal Article||Publisher:||Oxford University Press||Journal:||Bioinformatics||Volume:||32||Issue:||9||Start page:||1436||End page:||1438||Copyright (published version):||2016 the Authors||Keywords:||Epilepsy; MicroRNAs; RNA; Gene expression regulation; Biomarkers of epilepsy||DOI:||10.1093/bioinformatics/btw008||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Computer Science Research Collection|
Show full item record
Page view(s) 50188
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.