Repository logo
  • Log In
    New user? Click here to register.Have you forgotten your password?
University College Dublin
    Colleges & Schools
    Statistics
    All of DSpace
  • Log In
    New user? Click here to register.Have you forgotten your password?
  1. Home
  2. College of Science
  3. School of Computer Science
  4. Computer Science Research Collection
  5. EpimiRBase: a comprehensive database of microRNA-epilepsy associations
 
  • Details
Options

EpimiRBase: a comprehensive database of microRNA-epilepsy associations

Author(s)
Mooney, Catherine  
Becker, Brett A.  
Raoof, Rana  
Henshall, David C.  
Uri
http://hdl.handle.net/10197/10065
Date Issued
2016-01-08
Date Available
2019-04-23T08:54:58Z
Abstract
MicroRNAs are short non-coding RNA which function to fine-tune protein levels in all cells. This is achieved mainly by sequence-specific binding to 3′ untranslated regions of target mRNA. The result is post-transcriptional interference in gene expression which reduces protein levels either by promoting destabilisation of mRNA or translational repression. Research published since 2010 shows that microRNAs are important regulators of gene expression in epilepsy. A series of microRNA profiling studies in rodent and human tissue has revealed that epilepsy is associated with wide ranging changes to microRNA levels in the brain. These are thought to influence processes including cell death, inflammation and re-wiring of neuronal networks. MicroRNAs have also been identified in the blood after injury to the brain and therefore may serve as biomarkers of epilepsy. EpimiRBase is a manually curated database for researchers interested in the role of microRNAs in epilepsy. The fully searchable database includes information on up- and down-regulated microRNAs in the brain and blood, as well as functional studies, and covers both rodent models and human epilepsy.
Sponsorship
European Commission - Seventh Framework Programme (FP7)
Science Foundation Ireland
Other Sponsorship
Iraqi Ministry of Higher Education and Scientific Research
Type of Material
Journal Article
Publisher
Oxford University Press
Journal
Bioinformatics
Volume
32
Issue
9
Start Page
1436
End Page
1438
Copyright (Published Version)
2016 the Authors
Subjects

Epilepsy

MicroRNAs

RNA

Gene expression regul...

Biomarkers of epileps...

DOI
10.1093/bioinformatics/btw008
Language
English
Status of Item
Peer reviewed
ISSN
1367-4803
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
File(s)
No Thumbnail Available
Name

EpimiRBase.pdf

Size

240.55 KB

Format

Adobe PDF

Checksum (MD5)

2d00aa77713b36d4e84a68204e304402

Owning collection
Computer Science Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
All other content is subject to copyright.

For all queries please contact research.repository@ucd.ie.

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Cookie settings
  • Privacy policy
  • End User Agreement