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Peptigram: a web-based application for peptidomics data visualization
Date Issued
2016-12-02
Date Available
2019-04-25T09:08:30Z
Abstract
Tandem mass spectrometry (MS/MS) techniques, developed for protein identification, are increasingly being applied in the field of peptidomics. Using this approach, the set of protein fragments observed in a sample of interest can be determined to gain insights into important biological processes such as signaling and other bioactivities. As the peptidomics era progresses, there is a need for robust and convenient methods to inspect and analyze MS/MS derived data. Here, we present Peptigram, a novel tool dedicated to the visualization and comparison of peptides detected by MS/MS. The principal advantage of Peptigram is that it provides visualizations at both the protein and peptide level, allowing users to simultaneously visualize the peptide distributions of one or more samples of interest, mapped to their parent proteins. In this way rapid comparisons between samples can be made in terms of their peptide coverage and abundance. Moreover, Peptigram integrates and displays key sequence features from external databases and links with peptide analysis tools to offer the user a comprehensive peptide discovery resource. Here, we illustrate the use of Peptigram on a data set of milk hydrolysates. For convenience, Peptigram is implemented as a web application, and is freely available for academic use at http://bioware.ucd.ie/peptigram.
Sponsorship
Enterprise Ireland
Irish Research Council
Science Foundation Ireland
Other Sponsorship
Food for Health Ireland
Type of Material
Journal Article
Publisher
ACS Publications
Journal
Journal of Proteome Research
Volume
16
Issue
2
Start Page
712
End Page
719
Copyright (Published Version)
2016 American Chemical Society
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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