Bioorganometallic Chemistry: A Key To New Chemotherapy?
|Title:||Bioorganometallic Chemistry: A Key To New Chemotherapy?||Authors:||Hogan, Megan
|Permanent link:||http://hdl.handle.net/10197/10178||Date:||12-Jun-2009||Online since:||2019-04-29T08:51:11Z||Abstract:||6-Substituted fulvenes are interesting and easily accessible starting materials for the synthesis of novel substituted titanocenes via reductive dimerisation, carbolithiation or hydridolithiation reactions, which are followed by a transmetallation reaction with titanium tetrachloride in the latter two cases. Depending on the substitution pattern, these titanocenes prove to be bioorganometallic anticancer drugs, which have significant potential against advanced or metastatic renal-cell cancer. Patients bearing these stages of kidney cancer have a poor prognosis so far and therefore real progress in the area of metal-based anticancer drugs may come from this simple and effective synthetic approach.||Funding Details:||Higher Education Authority
University College Dublin
|Type of material:||Conference Publication||Publisher:||Slovak University of Technology||Series/Report no.:||Volume 9||Copyright (published version):||2009 Press of Slovak University of Technology, Bratislava||Keywords:||Metal-based drugs targeting cancer; Titanium-based reagents; Budotitane; Cremophor EL® based formulation; Metastatic renal-cell carcinoma; Metastatic breast cancer||Language:||en||Status of Item:||Peer reviewed||Is part of:||Melnik, M., Segl'a, P., Tatarko, M. (eds.). Insights into Coordination, Bioinorganic and Applied Inorganic Chemistry||Conference Details:||The 22th International Conference on Coordination and Bioinorganic Chemistry, Smolenice, Slovakia, June 7 - 12, 2009||ISBN:||9788022730853|
|Appears in Collections:||Conway Institute Research Collection|
Chemistry Research Collection
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