Bioorganometallic Chemistry: A Key To New Chemotherapy?

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Title: Bioorganometallic Chemistry: A Key To New Chemotherapy?
Authors: Hogan, Megan
Tacke, Matthias
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Date: 12-Jun-2009
Online since: 2019-04-29T08:51:11Z
Abstract: 6-Substituted fulvenes are interesting and easily accessible starting materials for the synthesis of novel substituted titanocenes via reductive dimerisation, carbolithiation or hydridolithiation reactions, which are followed by a transmetallation reaction with titanium tetrachloride in the latter two cases. Depending on the substitution pattern, these titanocenes prove to be bioorganometallic anticancer drugs, which have significant potential against advanced or metastatic renal-cell cancer. Patients bearing these stages of kidney cancer have a poor prognosis so far and therefore real progress in the area of metal-based anticancer drugs may come from this simple and effective synthetic approach.
Funding Details: Higher Education Authority
University College Dublin
Type of material: Conference Publication
Publisher: Slovak University of Technology
Series/Report no.: Volume 9
Copyright (published version): 2009 Press of Slovak University of Technology, Bratislava
Keywords: Metal-based drugs targeting cancerTitanium-based reagentsBudotitaneCremophor EL® based formulationMetastatic renal-cell carcinomaMetastatic breast cancer
Language: en
Status of Item: Peer reviewed
Is part of: Melnik, M., Segl'a, P., Tatarko, M. (eds.). Insights into Coordination, Bioinorganic and Applied Inorganic Chemistry
Conference Details: The 22th International Conference on Coordination and Bioinorganic Chemistry, Smolenice, Slovakia, June 7 - 12, 2009
ISBN: 9788022730853
Appears in Collections:Conway Institute Research Collection
Chemistry Research Collection

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