Novel Carbene-Metal Complexes as Anticancer Drugs and Antibiotics - Potential and Limitations

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Title: Novel Carbene-Metal Complexes as Anticancer Drugs and Antibiotics - Potential and Limitations
Authors: Tacke, Matthias
Permanent link: http://hdl.handle.net/10197/10231
Date: 1-Jun-2015
Online since: 2019-05-01T07:56:18Z
Abstract: Benzyl-substituted metallocarbene compounds synthesised during the past 5 years give a new perspective on their activity as antibiotic and antitumoral drugs. N-Heterocyclic carbene (NHC) containing Au and Ru compounds have shown promising anticancer activity in vitro and the Cu derivative WBC4 showed strong cytotoxic efficacy in vivo xenograft studies against difficult to treat renal cell cancer. While the carbene-silver acetate derivative SBC1 failed in vivo as an anticancer drug, the antibacterial derivative SBC3 convinced in vivo and this compound may lead the way towards novel injectable emergency antibiotics against resistant bacteria and fungi.
Type of material: Conference Publication
Publisher: Slovak University of Technology Publishing House
Series/Report no.: Volume 12, p.188-198
Copyright (published version): 2015 Slovak Chemical Society, Bratislava
Keywords: N-Heterocyclic carbene (NHC)SilverCopperGoldRutheniumAntibioticAnticancer drug
Other versions: http://www.iccbic.stuba.sk/index.htm
Language: en
Status of Item: Peer reviewed
Is part of: Melník, M., Segľa, P. and Tatarko, M. (eds.). Advancing Coordination, Bioinorganic and Applied Inorganic Chemistry
ISBN: 9788022730853
Appears in Collections:Chemistry Research Collection

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