Novel Carbene-Metal Complexes as Anticancer Drugs and Antibiotics - Potential and Limitations
|Title:||Novel Carbene-Metal Complexes as Anticancer Drugs and Antibiotics - Potential and Limitations||Authors:||Tacke, Matthias||Permanent link:||http://hdl.handle.net/10197/10231||Date:||1-Jun-2015||Online since:||2019-05-01T07:56:18Z||Abstract:||Benzyl-substituted metallocarbene compounds synthesised during the past 5 years give a new perspective on their activity as antibiotic and antitumoral drugs. N-Heterocyclic carbene (NHC) containing Au and Ru compounds have shown promising anticancer activity in vitro and the Cu derivative WBC4 showed strong cytotoxic efficacy in vivo xenograft studies against difficult to treat renal cell cancer. While the carbene-silver acetate derivative SBC1 failed in vivo as an anticancer drug, the antibacterial derivative SBC3 convinced in vivo and this compound may lead the way towards novel injectable emergency antibiotics against resistant bacteria and fungi.||Type of material:||Conference Publication||Publisher:||Slovak University of Technology Publishing House||Series/Report no.:||Volume 12, p.188-198||Copyright (published version):||2015 Slovak Chemical Society, Bratislava||Keywords:||N-Heterocyclic carbene (NHC); Silver; Copper; Gold; Ruthenium; Antibiotic; Anticancer drug||Other versions:||http://www.iccbic.stuba.sk/index.htm||Language:||en||Status of Item:||Peer reviewed||Is part of:||Melník, M., Segľa, P. and Tatarko, M. (eds.). Advancing Coordination, Bioinorganic and Applied Inorganic Chemistry||ISBN:||9788022730853|
|Appears in Collections:||Chemistry Research Collection|
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