Options
Novel Carbene-Metal Complexes as Anticancer Drugs and Antibiotics - Potential and Limitations
Author(s)
Date Issued
2015-06-01
Date Available
2019-05-01T07:56:18Z
Abstract
Benzyl-substituted metallocarbene compounds synthesised during the past 5 years give a new perspective on their activity as antibiotic and antitumoral drugs. N-Heterocyclic carbene (NHC) containing Au and Ru compounds have shown promising anticancer activity in vitro and the Cu derivative WBC4 showed strong cytotoxic efficacy in vivo xenograft studies against difficult to treat renal cell cancer. While the carbene-silver acetate derivative SBC1 failed in vivo as an anticancer drug, the antibacterial derivative SBC3 convinced in vivo and this compound may lead the way towards novel injectable emergency antibiotics against resistant bacteria and fungi.
Type of Material
Conference Publication
Publisher
Slovak University of Technology Publishing House
Series
Volume 12, p.188-198
Copyright (Published Version)
2015 Slovak Chemical Society, Bratislava
Web versions
Language
English
Status of Item
Peer reviewed
Part of
MelnÃk, M., Segľa, P. and Tatarko, M. (eds.). Advancing Coordination, Bioinorganic and Applied Inorganic Chemistry
ISBN
9788022730853
ISSN
1335-308X
This item is made available under a Creative Commons License
File(s)
Owning collection
Views
781
Acquisition Date
Mar 28, 2024
Mar 28, 2024
Downloads
95
Last Week
2
2
Last Month
3
3
Acquisition Date
Mar 28, 2024
Mar 28, 2024