Biological recognition of graphene nanoflakes

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Title: Biological recognition of graphene nanoflakes
Authors: Castagnola, Valentina
Zhao, W.
Boselli, Luca
Lo Giudice, Maria Cristina
Meder, Fabian
Polo, Ester
Dawson, Kenneth A.
Permanent link: http://hdl.handle.net/10197/10274
Date: 20-Apr-2018
Online since: 2019-05-02T09:25:24Z
Abstract: The systematic study of nanoparticle-biological interactions requires particles to be reproducibly dispersed in relevant fluids along with further development in the identification of biologically relevant structural details at the materials-biology interface. Here, we develop a biocompatible long-term colloidally stable water dispersion of few-layered graphene nanoflakes in the biological exposure medium in which it will be studied. We also report the study of the orientation and functionality of key proteins of interest in the biolayer (corona) that are believed to mediate most of the early biological interactions. The evidence accumulated shows that graphene nanoflakes are rich in effective apolipoprotein A-I presentation, and we are able to map specific functional epitopes located in the C-terminal portion that are known to mediate the binding of high-density lipoprotein to binding sites in receptors that are abundant in the liver. This could suggest a way of connecting the materials' properties to the biological outcomes.
Funding Details: European Commission Horizon 2020
European Commission - Seventh Framework Programme (FP7)
Irish Research Council
Science Foundation Ireland
University College Dublin
Type of material: Journal Article
Journal: Nature Communications
Volume: 9
Issue: 1
Copyright (published version): 2018 the Authors
Keywords: Biomaterials – proteinsNanoparticlesNanoparticle-biological interactionsGraphene nanoflakesLipoprotein
DOI: 10.1038/s41467-018-04009-x
Language: en
Status of Item: Peer reviewed
Appears in Collections:Centre for Bionano Interactions (CBNI) Research Collection
Chemistry Research Collection

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