Biological recognition of graphene nanoflakes

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dc.contributor.authorCastagnola, Valentina-
dc.contributor.authorZhao, W.-
dc.contributor.authorBoselli, Luca-
dc.contributor.authorLo Giudice, Maria Cristina-
dc.contributor.authorMeder, Fabian-
dc.contributor.authorPolo, Ester-
dc.contributor.authorDawson, Kenneth A.-
dc.date.accessioned2019-05-02T09:25:24Z-
dc.date.available2019-05-02T09:25:24Z-
dc.date.copyright2018 the Authorsen_US
dc.date.issued2018-04-20-
dc.identifier.citationNature Communicationsen_US
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10197/10274-
dc.description.abstractThe systematic study of nanoparticle-biological interactions requires particles to be reproducibly dispersed in relevant fluids along with further development in the identification of biologically relevant structural details at the materials-biology interface. Here, we develop a biocompatible long-term colloidally stable water dispersion of few-layered graphene nanoflakes in the biological exposure medium in which it will be studied. We also report the study of the orientation and functionality of key proteins of interest in the biolayer (corona) that are believed to mediate most of the early biological interactions. The evidence accumulated shows that graphene nanoflakes are rich in effective apolipoprotein A-I presentation, and we are able to map specific functional epitopes located in the C-terminal portion that are known to mediate the binding of high-density lipoprotein to binding sites in receptors that are abundant in the liver. This could suggest a way of connecting the materials' properties to the biological outcomes.en_US
dc.description.sponsorshipEuropean Commission Horizon 2020en_US
dc.description.sponsorshipEuropean Commission - Seventh Framework Programme (FP7)en_US
dc.description.sponsorshipIrish Research Councilen_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.description.sponsorshipUniversity College Dublinen_US
dc.language.isoenen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectBiomaterials – proteinsen_US
dc.subjectNanoparticlesen_US
dc.subjectNanoparticle-biological interactionsen_US
dc.subjectGraphene nanoflakesen_US
dc.subjectLipoproteinen_US
dc.titleBiological recognition of graphene nanoflakesen_US
dc.typeJournal Articleen_US
dc.statusPeer revieweden_US
dc.identifier.volume9en_US
dc.identifier.issue1en_US
dc.identifier.doi10.1038/s41467-018-04009-x-
dc.neeo.contributorCastagnola|Valentina|aut|-
dc.neeo.contributorZhao|W.|aut|-
dc.neeo.contributorBoselli|Luca|aut|-
dc.neeo.contributorLo Giudice|Maria Cristina|aut|-
dc.neeo.contributorMeder|Fabian|aut|-
dc.neeo.contributorPolo|Ester|aut|-
dc.neeo.contributorDawson|Kenneth A.|aut|-
dc.description.othersponsorshipUCD CSC Scholarship Schemeen_US
dc.description.othersponsorshipGerman Research Foundation (DFG)en_US
dc.identifier.grantid604391-
dc.identifier.grantidGOIPD/2016/128-
dc.identifier.grantid646364-
dc.identifier.grantid12/IA/1422-
dc.identifier.grantidME 4296/1-1-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85045908279-
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Centre for Bionano Interactions (CBNI) Research Collection
Chemistry Research Collection
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