Coinage Metal NHC Complexes as Novel Antibiotics and Anticancer Drugs

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Title: Coinage Metal NHC Complexes as Novel Antibiotics and Anticancer Drugs
Authors: Tacke, Matthias
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Date: 9-Jun-2017
Online since: 2019-05-07T12:49:24Z
Abstract: The synthesis and biological evaluation against cancer cells and pathogenic bacteria as well as fungi of five coinage metal NHC complexes derived from copper (WBC4), silver (SBC1/SBC3) and gold (NHC-Au-Cl/NHC-Au-SR) is reviewed. The NHC ligand for these compounds is 1,3-dibenzyl-4,5-diphenylimidazol-2-ylidene or derivatives closely related, since this ligand is proven suitable for drug-like molecules. The NHC-silver acetate complex SBC1 failed as an anticancer drug candidate in vivo, while its highly related compound SBC3 succeeded in vivo as an experimental antibiotic in Galleria mellonella larvae showing survival advantage against pathogenic bacteria and fungi. The corresponding gold complexes of NHC-Au-Cl and NHC-Au-SR (R = thioglucoside) as well as the NHC-copper bromide derivative WBC4 exhibited significant growth inhibition, when tested against xenografted human renal-cell cancer Caki-1 in nude mice; WBC4 showed tolerable toxicity in the form of reversible body weight loss, while the two gold compounds did not induce body weight loss in the xenograft mouse model experiment.
Funding Details: University College Dublin
Type of material: Conference Publication
Publisher: Slovak University of Technology Publishing House
Series/Report no.: Volume 13
Copyright (published version): 2017 Slovak Chemical Society
Keywords: Cancer cellsPathogenic bacteriaAnticancer drugElectron bond donorsSilver compound SBC3Renal-cell cancer
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Language: en
Status of Item: Not peer reviewed
Is part of: Melník, M., Segľa, P., Tatarko, M. (eds.). Modern Trends in Coordination, Bioinorganic, and Applied Inorganic Chemistry
Conference Details: The 26th International Conference on Coordination Chemistry (26th ICCBiC), Smolenice, Slovakia, 4-9 June 2017
ISBN: 978-80-89597-65-9
Appears in Collections:Chemistry Research Collection

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