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Assessing the State of an Organism and Toxicity of Substances Using Biochemical Indicators
Date Issued
2017-10-01
Date Available
2019-05-08T07:58:16Z
Abstract
Criteria for quantitatively describing the state and state variation of a living organism in various conditions are proposed using a set of its measurable characteristics (indicators, properties). The measurable indicators (of different origin and dimensionality) of an organism converted into a dimensionless form relative to their control values are combined into a single integral indicator showing relative deviation averaged over all the indicators. This integral indicator is useful to compare the results of different experiments. If the range of normal variability (reference range) is known for each indicator involved, the second integral indicator is proposed to be calculated as the normalized relative deviation from the middle of all reference ranges (in percentage) averaged over all the indicators. The calculation is performed in such a way that the range 0-100 % of this deviation of an indicator corresponds to the normal variability (where 0 corresponds to the middle of the reference range, 100 % - to its lower or upper limit), while the values over > 100 % represent a pathological response. The normalized relative deviation from the middle of all reference ranges (in percentage) averaged over all the indicators is an assessment of the state of a living organism (based on the given set of indicators) relative to the range of normal variability. The application of the suggested approach is illustrated by an example of a toxicological experiment.
Type of Material
Journal Article
Publisher
Karelian Research Centre of the Russian Academy of Sciences
Journal
Proceedings of the Karelian Research Centre of the Russian Academy of Sciences
Volume
9
Start Page
84
End Page
97
Copyright (Published Version)
2017 the Authors
Language
English
Status of Item
Not peer reviewed
ISSN
1997-3217
This item is made available under a Creative Commons License
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ASSESSING_THE_STATE_OF_AN_ORGANISM_AND_TOXICITY_OF.pdf
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Format
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