Can histone deacetylase inhibitors uncover novel therapeutic agents for inherited retinal dystrophies

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Title: Can histone deacetylase inhibitors uncover novel therapeutic agents for inherited retinal dystrophies
Authors: Sundaramurthi, HusvineeRueckert, H.Moran, AilísReynolds, AlisonKennedy, Breandán
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Date: 13-Dec-2017
Online since: 2019-05-08T14:06:55Z
Abstract: Inherited retinal dystrophies (iRDs) affect 1 in 3000 people worldwide and effective treatment options are not widely available due to the genetic and clinical heterogeneity. Recently, histone deacetylase inhibitors (HDACi) have gained attention as a potential therapeutic option based on their neuroprotective effects within the retina. However, the benefits of HDACi remains highly controversial, and their downstream mechanism of action are yet to be thoroughly elucidated. Preliminary data from studies conducted has shown that treatment of zebrafish retinal mutant with HDACi, trichostatin A (TSA), could rescue visual capacity and retinal morphology. The current study is designed to address the suitability of HDACi as therapeutic options for iRDs using zebrafish models.
metadata.dc.description.othersponsorship: Fighting Blindness
Type of material: Conference Publication
Keywords: Inherited retinal dystrophies (iRDs)Treatment optionsHistone deacetylase inhibitors (HDACi)Neuroprotective effectsRetinaVisual capacityRetinal morphology
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Language: en
Status of Item: Peer reviewed
Conference Details: British Pharmacological Society (BPS) Pharmacology 2017, London, England, 11-13 December 2017
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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