Structure and elasticity of bush and brush-like models of the endothelial glycocalyx

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Title: Structure and elasticity of bush and brush-like models of the endothelial glycocalyx
Authors: Kabedev, Aleksei
Lobaskin, Vladimir
Permanent link: http://hdl.handle.net/10197/10390
Date: 10-Jan-2018
Online since: 2019-05-09T11:07:05Z
Abstract: The endothelial glycocalyx (EG), a sugar-rich layer that lines the luminal surface of blood vessels, is an important constituent of the vascular system. Although the chemical composition of the EG is fairly well known, there is no consensus regarding its ultrastructure. While previous experiments probed the properties of the layer at the continuum level, they did not provide sufficient insight into its molecular organisation. In this work, we investigate the EG mechanics using two simple brush and bush-like simulation models, and use these models to describe its molecular structure and elastic response to indentation. We analyse the relationship between the mechanical properties of the EG layer and several molecular parameters, including the filament bending rigidity, grafting density, and the type of ultrastructure. We show that variations in the glycan density determine the elasticity of the EG for small deformations, and that the normal stress may be effectively dampened by the EG layer, preventing the stress from being transferred to the cell membrane. Furthermore, our bush-like model allows us to evaluate the forces and energies required to overcome the mechanical resistance of the EG.
Funding Details: European Commission - Seventh Framework Programme (FP7)
Irish Research Council
Type of material: Journal Article
Publisher: Springer Nature
Journal: Scientific Reports
Volume: 8
Copyright (published version): 2017 the Authors
Keywords: Endothelial glycocalyx (EG)Vascular endotheliumGlycocalyxAtomic force microscopyStructure-activity relationshipAlgorithmsElasticityUltrastructure
DOI: 10.1038/s41598-017-18577-3
Language: en
Status of Item: Peer reviewed
Appears in Collections:Physics Research Collection

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