Assessment of Executive Functions in Preschool Children with Sickle Cell Anemia

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dc.contributor.authorDownes, Michelle-
dc.contributor.authorKirkham, Fenella J.-
dc.contributor.authorTelfer, Paul T.-
dc.contributor.authorDe Haan, Michelle- The International Neuropsychological Societyen_US
dc.identifier.citationJournal of the International Neuropsychological Societyen_US
dc.description.abstractObjectives: Children with sickle cell anemia (SCA) are commonly reported to experience executive dysfunction. However, the development of executive function (EF) in preschool-age children without stroke in this patient population has not been investigated so it is unclear when and how these deficits emerge. Methods: This case-control study examines the feasibility of assessing the early development of executive functioning in 22 preschool children years with SCA in the domains of processing speed, working memory, attention, inhibitory control, and cognitive flexibility, as well as everyday function, in comparison to matched control children. Results: A pattern of potential deficits in early emerging executive skills was observed in the domains of inhibitory control and cognitive flexibility. Parents reported no differences for everyday EF and no significant differences were observed for working memory and processing speed. Conclusions: Results suggest that deficits in everyday executive difficulties, working memory, and processing speed, as commonly reported for older children with SCA, may not yet have emerged at this early developmental stage, despite specific deficits in cognitive flexibility and inhibitory control on behavioral measures. The feasibility of using available executive measures with preschool age children to characterize the development of early EF skills is discussed.en_US
dc.publisherCambridge University Pressen_US
dc.rightsThis article has been published in a revised form in Journal of the International Neuropsychological Society This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © The International Neuropsychological Societyen_US
dc.subjectExecutive functionen_US
dc.subjectSickle cell diseaseen_US
dc.subjectCognitive flexibilityen_US
dc.titleAssessment of Executive Functions in Preschool Children with Sickle Cell Anemiaen_US
dc.typeJournal Articleen_US
dc.statusPeer revieweden_US
dc.citation.otherSpecial Issue: The Neuropsychology of Neurodevelopmental Disordersen_US
dc.neeo.contributorDe Haan|M|aut|-
dc.description.othersponsorshipChild Health Research Charitable Incorporated Organisationen_US
dc.description.othersponsorshipNational Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trusten_US
dc.description.othersponsorshipUniversity College Londonen_US
dc.description.othersponsorshipNational Institute for Health Research for Patient Benefit Streamen_US
dc.description.othersponsorshipAction Medical Researchen_US
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