Altered Neurophysiological Processing of Auditory Attention in Preschool Children With Sickle Cell Disease
|Title:||Altered Neurophysiological Processing of Auditory Attention in Preschool Children With Sickle Cell Disease||Authors:||Downes, Michelle; Kirkham, Fenella J.; Telfer, Paul T.; De Haan, Michelle||Permanent link:||http://hdl.handle.net/10197/10539||Date:||1-Sep-2017||Online since:||2019-05-20T12:42:19Z||Abstract:||Objective: Sickle cell disease (SCD) is a genetic red blood cell disorder that often leads to stroke and executive dysfunction in school-age children and adults. This study aimed to characterize the development of the neural correlates of selective attention, an early component of executive function, in preschool children with SCD. Methods: Auditory event-related potentials (ERPs) were recorded while children attended to a story stream in one ear and ignored a second story in the other ear interchangeably. In total, 12 patients (mean age = 5.5, 7 males) and 22 typically developing children (mean age = 4.4, 10 males) were included in the final analyses. Results: By 100 ms, more positive ERP amplitudes were observed for attended relative to unattended stimuli in typically developing children but not those with SCD, suggesting deficits in the ability to focus attention. Reduced attention effects were associated with lower performance intellectual quotient Conclusion: There are deficits in early attention modulation in young children with SCD.||Type of material:||Journal Article||Publisher:||Oxford University Press||Journal:||Journal of Pediatric Psychology||Volume:||43||Issue:||8||Start page:||856||End page:||869||Copyright (published version):||2017 the Authors||Keywords:||Academic functioning; Attention; Developmental disabilities; Neuropsychology; Sickle cell disease||DOI:||10.1093/jpepsy/jsx115||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Psychology Research Collection|
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