Nucleobase sensing using highly-sensitive surface-enhanced Raman spectroscopy templates comprising organic semiconductor peptide nanotubes and metal nanoparticles
|Title:||Nucleobase sensing using highly-sensitive surface-enhanced Raman spectroscopy templates comprising organic semiconductor peptide nanotubes and metal nanoparticles||Authors:||Almohammed, Sawsan
Rodriguez, Brian J.
Rice, James H.
|Permanent link:||http://hdl.handle.net/10197/10587||Date:||17-May-2019||Online since:||2019-05-21T13:55:13Z||Abstract:||Templates formed from aligned diphenylalanine nanotubes with plasmon-active metal nanoparticles are a promising nanocomposite for large-scale, rapid, stable, and cost-effective surface-enhanced Raman spectroscopy (SERS) substrates. The high sensitivity of such templates arises from an arrangement of densely packed plasmon-active silver nanoparticles that enhance the localized electromagnetic field and allow the detection of the nucleobases adenine, cytosine, thymine, uracil, and guanine at concentrations in the range 10−5 to 10−9 M. Blinking of the SERS signal is observed, indicating sensitivity down to the single or few molecule limit. Such blinking could result from charge transfer process. These results demonstrate the potential for using aligned diphenylalanine nanotube-metal nanoparticle templates for practical monitoring of biomolecules and are promising initial steps toward the use of peptide nanotube-based in diagnostic sensing applications.||Funding Details:||European Commission Horizon 2020||Type of material:||Journal Article||Publisher:||Elsevier BV||Journal:||Sensing and Bio-Sensing Research||Copyright (published version):||2019 the Authors||Keywords:||Diphenylalanine nanotubes; Nucleobases; Surface-enhanced Raman spectroscopy; Nanocomposites; Self-assembly; Organic template||DOI:||10.1016/j.sbsr.2019.100287||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Physics Research Collection|
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