Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update

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Title: Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
Authors: Maher, SamBrayden, David J.Casettari, LucaIllum, Lisbethet al.
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Date: 19-Jan-2019
Online since: 2019-05-29T10:19:32Z
Abstract: The application of permeation enhancers (PEs) to improve transport of poorly absorbed active pharmaceutical ingredients across the intestinal epithelium is a widely tested approach. Several hundred compounds have been shown to alter the epithelial barrier, and although the research emphasis has broadened to encompass a role for nanoparticle approaches, PEs represent a key constituent of conventional oral formulations that have progressed to clinical testing. In this review, we highlight promising PEs in early development, summarize the current state of the art, and highlight challenges to the translation of PE-based delivery systems into safe and effective oral dosage forms for patients.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: MDPI
Journal: Pharmaceutics
Volume: 11
Issue: 1
Start page: 1
End page: 23
Copyright (published version): 2019 the Authors
Keywords: Permeation enhancerOral deliveryFormulationPermeabilitySafetySimulated intestinal fluidHydrophobizationEpithelium
DOI: 10.3390/pharmaceutics11010041
Language: en
Status of Item: Peer reviewed
Appears in Collections:Veterinary Medicine Research Collection

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