NHC*-Gold(I) Bioconjugated to Carbohydrates and Peptides as Targeted Anticancer Drugs

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Title: NHC*-Gold(I) Bioconjugated to Carbohydrates and Peptides as Targeted Anticancer Drugs
Authors: Tacke, Matthias
Permanent link: http://hdl.handle.net/10197/10789
Date: 7-Jun-2019
Online since: 2019-06-11T09:20:22Z
Abstract: Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and potentially avoids side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent based on the stabilising and lipophilic properties of the 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene (NHC*) ligand. One possibility is the chemoselective thiosugar conjugation to NHC*-Au-Cl in order to have active uptake of the resulting NHC*-Au-SR primarily into tumour tissue through the Warburg effect. In addition, a strategy based on chemoselective cysteine conjugation of NHC*-Au-Cl to human serum albumin or Trastuzumab to potentiate drug-ligand ratio, pharmacokinetics, as well as drug efficacy and safety is presented. These strategies are essential steps forward towards the use of gold-based anticancer agents as targeted therapies.
Funding Details: University College Dublin
Type of material: Conference Publication
Publisher: Press of Slovak University of Technology, Bratislava
Start page: 92
End page: 97
Series/Report no.: Monograph Series of the International Conferences on Coordination and Bioinorganic Chemistry held periodically at Smolenice in Slovakia; Volume 14
Copyright (published version): 2019 Slovak Chemical Society, Bratislava
Keywords: Cytotoxic drugsCancer cellsAnticancer agentNHC*-Au-ClTherapies
Language: en
Status of Item: Peer reviewed
Is part of: Melník, M., Segľa, P., Tatarko, M. (eds.). Progressive trends in coordination, bioinorganic, and applied inorganic chemistry
Conference Details: XXVII International Conference on Coordination and Bioinorganic Chemistry, Bratislava, Slovakia, 2-7 June 2019
Appears in Collections:Chemistry Research Collection

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