NHC*-Gold(I) Bioconjugated to Carbohydrates and Peptides as Targeted Anticancer Drugs
|Title:||NHC*-Gold(I) Bioconjugated to Carbohydrates and Peptides as Targeted Anticancer Drugs||Authors:||Tacke, Matthias||Permanent link:||http://hdl.handle.net/10197/10789||Date:||7-Jun-2019||Online since:||2019-06-11T09:20:22Z||Abstract:||Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and potentially avoids side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent based on the stabilising and lipophilic properties of the 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene (NHC*) ligand. One possibility is the chemoselective thiosugar conjugation to NHC*-Au-Cl in order to have active uptake of the resulting NHC*-Au-SR primarily into tumour tissue through the Warburg effect. In addition, a strategy based on chemoselective cysteine conjugation of NHC*-Au-Cl to human serum albumin or Trastuzumab to potentiate drug-ligand ratio, pharmacokinetics, as well as drug efficacy and safety is presented. These strategies are essential steps forward towards the use of gold-based anticancer agents as targeted therapies.||Funding Details:||University College Dublin||Type of material:||Conference Publication||Publisher:||Press of Slovak University of Technology, Bratislava||Start page:||92||End page:||97||Series/Report no.:||Monograph Series of the International Conferences on Coordination and Bioinorganic Chemistry held periodically at Smolenice in Slovakia; Volume 14||Copyright (published version):||2019 Slovak Chemical Society, Bratislava||Keywords:||Cytotoxic drugs; Cancer cells; Anticancer agent; NHC*-Au-Cl; Therapies||Language:||en||Status of Item:||Peer reviewed||Is part of:||Melník, M., Segľa, P., Tatarko, M. (eds.). Progressive trends in coordination, bioinorganic, and applied inorganic chemistry||Conference Details:||XXVII International Conference on Coordination and Bioinorganic Chemistry, Bratislava, Slovakia, 2-7 June 2019|
|Appears in Collections:||Chemistry Research Collection|
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