The contribution of the maternal immune system to the establishment of pregnancy in cattle

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Title: The contribution of the maternal immune system to the establishment of pregnancy in cattle
Authors: Fair, Trudee
Permanent link: http://hdl.handle.net/10197/10825
Date: 28-Jan-2015
Online since: 2019-07-01T13:20:00Z
Abstract: Immune cells play an integral role in affecting successful reproductive function. Indeed, disturbed or aberrant immune function has been identified as primary mechanisms behind infertility. In contrast to the extensive body of literature that exists for human and mouse, studies detailing the immunological interaction between the embryo and the maternal endometrium are quite few in cattle. Nevertheless, by reviewing the existing studies and extrapolating from sheep, pig, mouse, and human data, we can draw a reasonably comprehensive picture. Key contributions of immune cell populations include granulocyte involvement in follicle differentiation and gamete transfer, monocyte invasion of the peri-ovulatory follicle and their subsequent role in corpus luteum formation and the pivotal roles of maternal macrophage and dendritic cells in key steps of the establishment of pregnancy, particularly, the maternal immune response to the embryo. These contributions are reviewed in detail below and key findings are discussed.
Type of material: Journal Article
Publisher: Frontiers Media SA
Journal: Frontiers in Immunology
Volume: 6
Issue: JAN
Copyright (published version): 2015 the Author
Keywords: CowFertilityMacrophageCytokineImmune function
DOI: 10.3389/fimmu.2015.00007
Language: en
Status of Item: Peer reviewed
Appears in Collections:Agriculture and Food Science Research Collection

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