The contribution of the maternal immune system to the establishment of pregnancy in cattle

DC FieldValueLanguage
dc.contributor.authorFair, Trudee-
dc.date.accessioned2019-07-01T13:20:00Z-
dc.date.available2019-07-01T13:20:00Z-
dc.date.copyright2015 the Authoren_US
dc.date.issued2015-01-28-
dc.identifier.citationFrontiers in Immunologyen_US
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10197/10825-
dc.description.abstractImmune cells play an integral role in affecting successful reproductive function. Indeed, disturbed or aberrant immune function has been identified as primary mechanisms behind infertility. In contrast to the extensive body of literature that exists for human and mouse, studies detailing the immunological interaction between the embryo and the maternal endometrium are quite few in cattle. Nevertheless, by reviewing the existing studies and extrapolating from sheep, pig, mouse, and human data, we can draw a reasonably comprehensive picture. Key contributions of immune cell populations include granulocyte involvement in follicle differentiation and gamete transfer, monocyte invasion of the peri-ovulatory follicle and their subsequent role in corpus luteum formation and the pivotal roles of maternal macrophage and dendritic cells in key steps of the establishment of pregnancy, particularly, the maternal immune response to the embryo. These contributions are reviewed in detail below and key findings are discussed.en_US
dc.format.mediumElectronic-eCollection-
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectCowen_US
dc.subjectFertilityen_US
dc.subjectMacrophageen_US
dc.subjectCytokineen_US
dc.subjectImmune functionen_US
dc.titleThe contribution of the maternal immune system to the establishment of pregnancy in cattleen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothertrudee.fair@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume6en_US
dc.identifier.issueJANen_US
dc.identifier.doi10.3389/fimmu.2015.00007-
dc.neeo.contributorFair|Trudee|aut|-
dc.date.updated2019-06-24T14:19:39Z-
item.fulltextWith Fulltext-
item.grantfulltextopen-
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