Recommended Reading from Cedars-Sinai Medical Center Fellows

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Title: Recommended Reading from Cedars-Sinai Medical Center Fellows
Authors: Coyle Rowan, SimonBora, StephanieBurman, AnkitaXie, Ting
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Date: 2-Jul-2019
Online since: 2019-07-24T09:04:13Z
Abstract: Idiopathic pulmonary fibrosis (IPF) is a severe disease with no cure, and a median survival rate of < 5 years (1). Other research indicates the cytokine IL-17 is part of the pro-fibrotic inflammatory response (2). The critical influence of the gut microbiome in IL-17 immune responses has been established (3), yet the role of the lung microbiota in lung inflammation, and specifically IL-17 responses that promote IPF, is overlooked. In their Immunity paper, Yang et al used the bleomycin model of fibrosis to determine if IL-17B, one of six IL-17 cytokines, caused lung fibrosis, and if the lung microbiome regulated pro-fibrotic IL-17 production.
Type of material: Review
Publisher: American Thoracic Society
Journal: American Journal of Respiratory Cell and Molecular Biology
Copyright (published version): 2019 American Thoracic Society
Keywords: Idiopathic pulmonary fibrosis (IPF)MicrobiomeInflammatoryLung
DOI: 10.1165/rcmb.2019-0196ro
Language: en
Status of Item: Peer reviewed
Appears in Collections:Medicine Research Collection

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