Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions
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|Title:||Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions||Authors:||Brennan, Lorraine; Gibbons, Helena||Permanent link:||http://hdl.handle.net/10197/10957||Date:||31-Jul-2019||Online since:||2019-08-07T13:10:37Z||Abstract:||The metabolomic profile of a biofluid can be altered by dietary intake, exercise and disease processes and, thus provides an important tool for the study of many physiological processes. However, in addition to perturbation due to disease, the metabolomic profile of urine and plasma has also been shown to vary due to many intrinsic physiological factors such as age, sex, hormonal status and diurnal variation. Characterisation of this normal degree of variation in the metabolomic profiles of human biofluids is a necessary and important step in the development of metabolomics for use in nutrition-related research. The current review focuses on the impact of sex on the metabolomic profile. A number of studies have reported that sex impacts metabolites such as amino acids, lipids, sugars and keto acids. Furthermore, we examine the effect of the menstrual cycle on the metabolomic profile. Responses to dietary interventions can also differ between the sexes and highlighting this is important for the development of the field of precision nutrition.||Funding Details:||European Commission Horizon 2020||Type of material:||Journal Article||Publisher:||Cambridge University Press (CUP)||Journal:||Proceedings of the Nutrition Society||Start page:||1||End page:||5||Copyright (published version):||2019 the Authors||Keywords:||Metabolomics; Sex; Dietary interventions; MedDiet; Mediterranean diet; Precision Nutrition||DOI:||10.1017/s002966511900106x||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Agriculture and Food Science Research Collection|
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