Metabotyping and its role in nutrition research

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Title: Metabotyping and its role in nutrition research
Authors: Hillesheim, ElaineBrennan, Lorraine
Permanent link: http://hdl.handle.net/10197/11047
Date: 22-Aug-2019
Online since: 2019-08-27T06:57:48Z
Abstract: Personalised nutrition is at its simplest form the delivery of dietary advice at an individual level. Incorporating response to different diets has resulted in the concept of precision nutrition. Harnessing the metabolic phenotype to identify subgroups of individuals that respond differentially to dietary interventions is becoming a reality. More specifically, the classification of individuals in subgroups according to their metabolic profile is defined as metabotyping and this approach has been employed to successfully identify differential response to dietary interventions. Furthermore, the approach has been expanded to develop a framework for the delivery of targeted nutrition. The present review examines the application of the metabotype approach in nutrition research with a focus on developing personalised nutrition. Application of metabotyping in longitudinal studies demonstrates that metabotypes can be associated with cardiometabolic risk factors and diet-related diseases while application in interventions can identify metabotypes with differential responses. In general, there is strong evidence that metabolic phenotyping is a promising strategy to identify groups at risk and to potentially improve health promotion at a population level. Future work should verify if targeted nutrition can change behaviours and have an impact on health outcomes.
Funding Details: European Research Council
Type of material: Journal Article
Publisher: Cambridge University Press (CUP)
Journal: Nutrition Research Reviews
Start page: 1
End page: 10
Copyright (published version): 2019 the Authors
Keywords: Cluster analysisMetabotypesPersonalised nutritionTargeted nutrition
DOI: 10.1017/s0954422419000179
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Agriculture and Food Science Research Collection

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