The immunoregulatory effects of co-infection with Fasciola hepatica: From bovine tuberculosis to Johne's disease

Files in This Item:
File Description SizeFormat 
Amalia Review.pdf276.13 kBAdobe PDFDownload
Title: The immunoregulatory effects of co-infection with Fasciola hepatica: From bovine tuberculosis to Johne's disease
Authors: Naranjo Lucena, AmaliaGarza-Cuartero, LauraMulcahy, GraceZintl, Annetta
Permanent link: http://hdl.handle.net/10197/11232
Date: Apr-2017
Online since: 2019-12-06T12:43:00Z
Abstract: Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale. This review explores the immunological consequences of co-infection between F. hepatica and other bacterial infections. Arguments are presented suggesting that immunity of cattle to Mycobacterium avium subsp. paratuberculosis is also likely to be affected.
Funding Details: European Commission Horizon 2020
Type of material: Journal Article
Publisher: Elsevier
Journal: The Veterinary Journal
Volume: 222
Start page: 9
End page: 16
Copyright (published version): 2017 Elsevier
Keywords: AnimalsCattleFasciola hepaticaParatuberculosisTuberculosis, BovineFascioliasisCattle diseasesMycobacterium avium subsp. paratuberculosisImmunomodulationCoinfectionJohne's disease
DOI: 10.1016/j.tvjl.2017.02.007
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Veterinary Medicine Research Collection

Show full item record

SCOPUSTM   
Citations 50

6
Last Week
1
Last month
checked on Jan 21, 2020

Page view(s)

674
Last Week
22
Last month
checked on Jan 23, 2020

Download(s)

156
checked on Jan 23, 2020

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.