The immunoregulatory effects of co-infection with Fasciola hepatica: From bovine tuberculosis to Johne's disease
|Title:||The immunoregulatory effects of co-infection with Fasciola hepatica: From bovine tuberculosis to Johne's disease||Authors:||Naranjo Lucena, Amalia; Garza-Cuartero, Laura; Mulcahy, Grace; Zintl, Annetta||Permanent link:||http://hdl.handle.net/10197/11232||Date:||Apr-2017||Online since:||2019-12-06T12:43:00Z||Abstract:||Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale. This review explores the immunological consequences of co-infection between F. hepatica and other bacterial infections. Arguments are presented suggesting that immunity of cattle to Mycobacterium avium subsp. paratuberculosis is also likely to be affected.||Funding Details:||European Commission Horizon 2020||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||The Veterinary Journal||Volume:||222||Start page:||9||End page:||16||Copyright (published version):||2017 Elsevier||Keywords:||Animals; Cattle; Fasciola hepatica; Paratuberculosis; Tuberculosis, Bovine; Fascioliasis; Cattle diseases; Mycobacterium avium subsp. paratuberculosis; Immunomodulation; Coinfection; Johne's disease||DOI:||10.1016/j.tvjl.2017.02.007||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Conway Institute Research Collection|
Veterinary Medicine Research Collection
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