A Thalamo-Cortex Microcircuit Model of Beta Oscillations in the Parkinsonian Motor Cortex

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Title: A Thalamo-Cortex Microcircuit Model of Beta Oscillations in the Parkinsonian Motor Cortex
Authors: Farokhniaee, AmirAliLowery, Madeleine M.
Permanent link: http://hdl.handle.net/10197/11277
Date: 27-Jul-2019
Online since: 2020-02-13T11:21:46Z
Abstract: Exaggerated beta oscillations (~13-30 Hz) observed in the cortical areas of the brain is one of the characteristics of disrupted information flow in the primary motor cortex in Parkinson’s disease (PD). However, the mechanism underlying the generation of these enhanced beta rhythms remains unclear. The thalamo-cortex microcircuit (TCM) contains reciprocal synaptic connections that generate low frequency oscillations in the microcircuit in healthy conditions. Recent studies suggest that alterations in synaptic connections both within and between the cortex and thalamus play a critical role in the generation of pathological beta rhythms in PD. In this study, we examine this hypothesis in a spiking neuronal network model of the TCM. The model is compared and validated against neural firing patterns recorded in rodent models of PD from the literature.
Funding Details: European Commission Horizon 2020
European Research Council
metadata.dc.description.othersponsorship: Insight Research Centre
Type of material: Conference Publication
Publisher: IEEE
Copyright (published version): 2019 IEEE
Keywords: NeurosciencesAcquired cognitive impairmentBrain disordersNeurodegenerativeAgingParkinson's diseaseNormal biological development and functioningNeurological
DOI: 10.1109/embc.2019.8857790
Other versions: https://embc.embs.org/2019/
Language: en
Status of Item: Peer reviewed
Conference Details: The 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Berlin, Germany, 23-27 July 2019
ISBN: 978-1-5386-1311-5/19
Appears in Collections:Electrical and Electronic Engineering Research Collection
Insight Research Collection

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