Changes in Neuronal Entropy in a Network Model of the Cortico-Basal Ganglia during Deep Brain Stimulation

DC FieldValueLanguage
dc.contributor.authorFleming, John E.-
dc.contributor.authorLowery, Madeleine M.-
dc.date.accessioned2020-02-13T12:07:28Z-
dc.date.available2020-02-13T12:07:28Z-
dc.date.copyright2019 IEEEen_US
dc.date.issued2019-07-27-
dc.identifier.isbn978-1-5386-1311-5-
dc.identifier.issn1558-4615-
dc.identifier.urihttp://hdl.handle.net/10197/11280-
dc.descriptionThe 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany, 23-27 July 2019en_US
dc.description.abstractNeuronal entropy changes are observed in the basal ganglia circuit in Parkinson’s disease (PD). These changes are observed in both single unit recordings from globus pallidus (GP) neurons and in local field potential (LFP) recordings from the subthalamic nucleus (STN). These changes are hypothesized as representing changes in the information coding capacity of the network, with PD resulting in a reduction in the coding capacity of the basal ganglia network. Entropy changes in the LFP and in single unit recordings are investigated in a detailed physiological model of the cortico-basal ganglia network during STN deep brain stimulation (DBS). The model incorporates extracellular stimulation of STN afferent fibers, with both orthodromic and antidromic activation, and simulation of the LFP detected at a differential recording electrode. LFP sample entropy and beta-band oscillation power were found to be altered following the application of DBS. The ring pattern entropy of GP neurons in the network were observed to decrease during high frequency stimulation and increase during low frequency stimulation. Simulation results were consistent with experimentally reported changes in neuronal entropy during DBS.en_US
dc.description.sponsorshipEuropean Commission Horizon 2020en_US
dc.description.sponsorshipEuropean Research Councilen_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.rights© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en_US
dc.subjectNeurodegenerativeen_US
dc.subjectNeurosciencesen_US
dc.subjectRehabilitationen_US
dc.subjectBioengineeringen_US
dc.subjectParkinson's diseaseen_US
dc.subjectAgingen_US
dc.subjectBrain disordersen_US
dc.subjectAssistive technologyen_US
dc.subjectNeurologicalen_US
dc.titleChanges in Neuronal Entropy in a Network Model of the Cortico-Basal Ganglia during Deep Brain Stimulationen_US
dc.typeConference Publicationen_US
dc.internal.authorcontactotheraoife.ogorman@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.doi10.1109/embc.2019.8857440-
dc.neeo.contributorFleming|John E.|aut|-
dc.neeo.contributorLowery|Madeleine M.|aut|-
dc.description.othersponsorshipInsight Research Centreen_US
dc.description.admin2020-02-13 JG: docx replaced with INSIGHT submitted PDFen_US
dc.date.updated2019-12-12T10:31:42Z-
dc.identifier.grantidERC-2014-CoG-646923-DBSModel-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en
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item.grantfulltextopen-
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