Effect of moderate Cu supplementation on serum metabolites, enzymes and redox state in feedlot calves

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Title: Effect of moderate Cu supplementation on serum metabolites, enzymes and redox state in feedlot calves
Authors: Castillo, CristinaHernández, JoaquinGarcía-Vaquero, Marco
Permanent link: http://hdl.handle.net/10197/11298
Date: Aug-2012
Online since: 2020-03-05T15:24:36Z
Abstract: The aim of this investigation was to evaluate whether, in the nutritional management of commercial feedlots, copper (Cu) supplementation is justified to maintain the physiological requirements. This study compared beef calves fed concentrates with an average Cu basal content of 5 and 8. mg/kg in growing and finishing periods (10 animals) or supplemented with 15. mg/kg for each phase (20 animals) as regards production indices, metabolic parameters [glucose, nonesterified fatty acids (NEFA), cholesterol, serum urea nitrogen (SUN), creatinine, total serum protein (TSP), albumin, aspartate transaminase (AST) and γ-glutamyl transferase (GGT)] and markers of oxidative stress (reactive oxygen species (ROS) and serum antioxidant capacity (SAC)). Data were recorded at ages 12, 24 and 36. weeks. In general, Cu supplementation was neither detrimental nor beneficial for animal health and performance, and the levels of the measured metabolites and enzymes were within their normal ranges stated for feedlot with the same management during the whole study. However, in keeping with reported higher hepatic Cu levels at slaughter, animals on supplemented feed had higher GGT activities at the end of the finishing stage, although the difference was not statistically significant. On the other hand, lower SAC levels at the end of the growing period in the supplemented group suggest the possibility of a positive effect of Cu supplementation on redox state. Further research is necessary to clarify the potential role of Cu in limiting the ROS production associated with fattening diets, and to evaluate the hepatobiliary consequences of supplementation, including hepatic Cu accumulation. © 2011 Elsevier Ltd.
Funding Details: Xunta de Galicia, Spain
Type of material: Journal Article
Publisher: Elsevier
Journal: Research in Veterinary Science
Volume: 93
Issue: 1
Start page: 269
End page: 274
Copyright (published version): 2011 Elsevier
Keywords: CattleCopperReactive oxygen speciesCholesterolGamma-glutamyltransferaseAspartate aminotransferasesBlood glucoseNonestrified fatty acidsBlood urea nitrogenOxidation-reductionDietary supplementsAnimal nutritional physiological phenomena
DOI: 10.1016/j.rvsc.2011.06.014
Language: en
Status of Item: Peer reviewed
ISSN: 0034-5288
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Agriculture and Food Science Research Collection

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