The interlobular distribution of copper in the liver of beef calves on a high-copper diet

Title: The interlobular distribution of copper in the liver of beef calves on a high-copper diet
Authors: Miranda, MartaBenedito, José LuisGutiérrez, BetianaGarcía-Vaquero, MarcoBlanco-Penedo, IsabelLópez-Alonso, Marta
Permanent link:
Date: 1-Mar-2010
Online since: 2020-03-06T12:51:54Z
Abstract: The aims of the present study were 1) to evaluate the interlobular distribution of copper (Cu) in the liver of beef calves on a high-Cu diet, 2) to determine whether this distribution differs between Galician Blonds and Holstein Friesians, and 3) to determine whether in vivo needle biopsy provides an appropriate measure of overall hepatic Cu status. Liver biopsies were performed before slaughter on twenty-nine 10-month-old beef calves fed growing and finishing diets supplemented with 35 mg/kg of Cu sulfate (10 Galician Blonds, 9 Holstein Friesians, and 10 Galician Blond × Holstein Friesian crosses). At slaughter, samples taken from 6 regions of the liver (the internal and external faces of the right lobe; the left, caudate, and quadrate lobes; and the processus papillaris) were acid digested, and their Cu contents were determined by inductively coupled plasma atomic emission spectrometry. The highest Cu concentrations were found in the left lobe, followed by the processus papillaris, and the lowest Cu concentrations were found in the caudate and quadrate lobes. Different breeds differ in absolute hepatic Cu levels, but interlobular Cu distribution does not appear to depend on breed, at least when Galician Blonds are compared with Holstein Friesians. In vivo needle biopsy afforded accurate estimates of overall hepatic Cu status.
metadata.dc.description.othersponsorship: Xunta de Galicia
University of Santiago de Compostela
Type of material: Journal Article
Publisher: Sage
Journal: Journal of Veterinary Diagnostic Investigation
Volume: 22
Issue: 2
Start page: 277
End page: 281
Keywords: LiverAnimalsCattleCopperDietAnimal feedDietary supplementsAnimal nutritional physiological phenomena
DOI: 10.1177/104063871002200221
Language: en
Status of Item: Peer reviewed
Appears in Collections:Agriculture and Food Science Research Collection

Show full item record

Citations 50

Last Week
Last month
checked on Mar 31, 2020

Page view(s)

Last Week
Last month
checked on Apr 7, 2020


checked on Apr 7, 2020

Google ScholarTM



This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.