Repository logo
  • Log In
    New user? Click here to register.Have you forgotten your password?
University College Dublin
    Colleges & Schools
    Statistics
    All of DSpace
  • Log In
    New user? Click here to register.Have you forgotten your password?
  1. Home
  2. College of Science
  3. School of Physics
  4. Physics Research Collection
  5. PEAR Nanoscopy: Accelerating the in-depth understanding of biomedical processes at the nanoscale via a novel real-time, optical limit-breaking imaging technology
 
  • Details
Options

PEAR Nanoscopy: Accelerating the in-depth understanding of biomedical processes at the nanoscale via a novel real-time, optical limit-breaking imaging technology

Author(s)
Gordon, John David  
O'Toole, Silas  
Kühne, Irina Alexandra  
Scholz, Dimitri  
Zerulla, Dominic  
Uri
http://hdl.handle.net/10197/11338
Date Issued
2019-09-24
Date Available
2020-04-03T15:23:31Z
Abstract
PEAR offers an innovative solution for the next generation of microscopy. The method achieves imaging beyond the far-field diffraction limit (~200 nm) via addressable plasmonic elements, which act similar to sensor pixels, offering below 25 nm spatial resolution. The photonic chip contains an electronically addressable array of metallic nano-elements, acting as quasi-pixels. These pixels can be switched from "on-resonance" to "off-resonance" via a modulated current. This modulation results in appreciable changes of the electric near-field strength above the pixels, which can be detected via optical heterodyne detection. The ability to rapidly address these active plasmonic elements and to encode information in the way the pixels are addressed enables retrieval of spatial information in the far-field, leading to sub-diffraction-limit imaging. Because of the known, nano-localised addressability of the modulation, a dedicated computer algorithm is capable of extracting the contained information. A second benefit of the pixel-addressing is the resulting capability to read-out all the spatial information in one step, which leads to unprecedented speed of image acquisition hence providing real-time imaging of biological systems at the nanoscale level. This award-winning solution is bio-compatible and can easily be retrofitted into existing commercially available microscopes and will provide a greatly improved in-depth understanding of subcellular mechanisms and even macromolecular reactions in real-time. In order to provide evidence for the capabilities of our new invention we have chosen to focus onto the transfer mechanism of melanin granules by filopodia as a relevant proof of concept.
Sponsorship
European Commission Horizon 2020
Irish Research Council
Science Foundation Ireland
Type of Material
Conference Publication
Subjects

Microscopy

Spatial resolution

Photonic chips

Language
English
Status of Item
Peer reviewed
Conference Details
Conway Festival of Research & Innovation, University College Dublin, 25-26 September 2019
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
File(s)
Loading...
Thumbnail Image
Name

FRI19_UCD Conway Festival Medal_ Abstract_DZ.pdf

Size

165.54 KB

Format

Adobe PDF

Checksum (MD5)

ac36f514d392650fc10de1bf6c71b5b1

Owning collection
Physics Research Collection
Mapped collections
Conway Institute Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
All other content is subject to copyright.

For all queries please contact research.repository@ucd.ie.

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Cookie settings
  • Privacy policy
  • End User Agreement