Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.

Files in This Item:
File Description SizeFormat 
T Cordifolia compound docking with figure.pdf1.13 MBAdobe PDFDownload
Title: Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.
Authors: Sagar, VasanthkumarKumar, Arun H.S.
Permanent link: http://hdl.handle.net/10197/11380
Date: 8-May-2020
Online since: 2020-05-22T12:01:11Z
Abstract: Background: Antiviral activity of natural compounds from Tinospora cordifolia (Amritaballi) were evaluated for their efficacy against SARS-CoV-2 targets involved in virus attachment and replication.Materials and Methods: The binding efficacy (binding affinity, Ki and IC50 values) of natural compounds from Tinospora cordifolia were tested using Insilco tools against four key SARS-CoV-2 targets i.e., 1) surface glycoprotein (6VSB) and 2) Receptor binding domain (6M0J) both responsible for attachment of the virus to host cell, 3) RNA dependent RNA polymerase (6M71) and 4) main protease (6Y84) responsible for replication of the virus in the host cell.Results: Berberine, Isocolumbin, Magnoflorine and Tinocordiside showed high binding efficacy against all the four key SARS-CoV-2 targets. Tinocordiside and Isocolumbin showed IC50 value of < 1 µM against both 6Y84 and 6VSB.Conclusion: At least four natural compounds from Tinospora cordifolia showed high binding efficacy against SARS-CoV-2 targets involved in attachment and replication of the virus. Hence validating the merit of using Tinospora cordifolia in the clinical management of infection caused by SARS-CoV-2.
Funding Details: University College Dublin
metadata.dc.description.othersponsorship: Royal Society-UK
Stemcology
Type of material: Journal Article
Publisher: Research Square
Journal: Virology
Start page: 1
End page: 10
Keywords: Protease inhibitorsRNA polymerase inhibitorsCoronavirusCovid-19Antiviral drugsSARS-CoV-2Viral entry
DOI: 10.21203/rs.3.rs-27375/v1
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Veterinary Medicine Research Collection

Show full item record

Page view(s)

107
checked on Jun 3, 2020

Download(s)

25
checked on Jun 3, 2020

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.