Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.
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|Title:||Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.||Authors:||Sagar, Vasanthkumar; Kumar, Arun H.S.||Permanent link:||http://hdl.handle.net/10197/11380||Date:||8-May-2020||Online since:||2020-05-22T12:01:11Z||Abstract:||Background: Antiviral activity of natural compounds from Tinospora cordifolia (Amritaballi) were evaluated for their efficacy against SARS-CoV-2 targets involved in virus attachment and replication.Materials and Methods: The binding efficacy (binding affinity, Ki and IC50 values) of natural compounds from Tinospora cordifolia were tested using Insilco tools against four key SARS-CoV-2 targets i.e., 1) surface glycoprotein (6VSB) and 2) Receptor binding domain (6M0J) both responsible for attachment of the virus to host cell, 3) RNA dependent RNA polymerase (6M71) and 4) main protease (6Y84) responsible for replication of the virus in the host cell.Results: Berberine, Isocolumbin, Magnoflorine and Tinocordiside showed high binding efficacy against all the four key SARS-CoV-2 targets. Tinocordiside and Isocolumbin showed IC50 value of < 1 µM against both 6Y84 and 6VSB.Conclusion: At least four natural compounds from Tinospora cordifolia showed high binding efficacy against SARS-CoV-2 targets involved in attachment and replication of the virus. Hence validating the merit of using Tinospora cordifolia in the clinical management of infection caused by SARS-CoV-2.||Funding Details:||University College Dublin||metadata.dc.description.othersponsorship:||Royal Society-UK
|Type of material:||Journal Article||Publisher:||Research Square||Journal:||Virology||Start page:||1||End page:||10||Keywords:||Protease inhibitors; RNA polymerase inhibitors; Coronavirus; COVID-19; Antiviral drugs; SARS-CoV-2; Viral entry||DOI:||10.21203/rs.3.rs-27375/v1||Language:||en||Status of Item:||Not peer reviewed|
|Appears in Collections:||Veterinary Medicine Research Collection|
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