Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.

DC FieldValueLanguage
dc.contributor.authorSagar, Vasanthkumar-
dc.contributor.authorKumar, Arun H.S.-
dc.date.accessioned2020-05-22T12:01:11Z-
dc.date.available2020-05-22T12:01:11Z-
dc.date.issued2020-05-08-
dc.identifier.citationVirologyen_US
dc.identifier.issn0042-6822-
dc.identifier.urihttp://hdl.handle.net/10197/11380-
dc.description.abstractBackground: Antiviral activity of natural compounds from Tinospora cordifolia (Amritaballi) were evaluated for their efficacy against SARS-CoV-2 targets involved in virus attachment and replication.Materials and Methods: The binding efficacy (binding affinity, Ki and IC50 values) of natural compounds from Tinospora cordifolia were tested using Insilco tools against four key SARS-CoV-2 targets i.e., 1) surface glycoprotein (6VSB) and 2) Receptor binding domain (6M0J) both responsible for attachment of the virus to host cell, 3) RNA dependent RNA polymerase (6M71) and 4) main protease (6Y84) responsible for replication of the virus in the host cell.Results: Berberine, Isocolumbin, Magnoflorine and Tinocordiside showed high binding efficacy against all the four key SARS-CoV-2 targets. Tinocordiside and Isocolumbin showed IC50 value of < 1 µM against both 6Y84 and 6VSB.Conclusion: At least four natural compounds from Tinospora cordifolia showed high binding efficacy against SARS-CoV-2 targets involved in attachment and replication of the virus. Hence validating the merit of using Tinospora cordifolia in the clinical management of infection caused by SARS-CoV-2.en_US
dc.description.sponsorshipUniversity College Dublinen_US
dc.language.isoenen_US
dc.publisherResearch Squareen_US
dc.subjectProtease inhibitorsen_US
dc.subjectRNA polymerase inhibitorsen_US
dc.subjectCoronavirusen_US
dc.subjectCOVID-19en_US
dc.subjectAntiviral drugsen_US
dc.subjectSARS-CoV-2en_US
dc.subjectViral entryen_US
dc.titleEfficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.en_US
dc.typeJournal Articleen_US
dc.internal.authorcontactotherarun.kumar@ucd.ieen_US
dc.statusNot peer revieweden_US
dc.identifier.startpage1en_US
dc.identifier.endpage10en_US
dc.identifier.doi10.21203/rs.3.rs-27375/v1-
dc.neeo.contributorSagar|Vasanthkumar|aut|-
dc.neeo.contributorKumar|Arun H.S.|aut|-
dc.description.othersponsorshipRoyal Society-UKen_US
dc.description.othersponsorshipStemcologyen_US
dc.date.updated2020-05-13T20:27:22Z-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en
item.fulltextWith Fulltext-
item.grantfulltextopen-
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