Metabolomic Based Approach to Identify Biomarkers of Apple Intake

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Title: Metabolomic Based Approach to Identify Biomarkers of Apple Intake
Authors: McNamara, Aoife E.Collins, CassandraHarsha, Pedapati S. C. SriGonzález-Peña, DianaGibbons, HelenaMcNulty, Breige A.Nugent, Anne P.Walton, JanetteFlynn, AlbertBrennan, Lorraine
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Date: Jun-2020
Online since: 2020-06-23T11:36:55Z
Abstract: SCOPE:There is an increased interest in developing biomarkers of food intake to address some of the limitations associated with self-reported data. The objective was to identify biomarkers of apple intake, examine dose-response relationships and agreement with self-reported data. METHODS AND RESULTS:Metabolomic data from three studies were examined: an acute intervention, a short-term intervention and a free-living cohort study. Fasting and postprandial urine samples were collected for analysis by 1 H-NMR and LC-MS. Calibration curves were developed to determine apple intake and classify individuals into categories of intake. Multivariate analysis of data revealed that levels of multiple metabolites increased significantly post-apple consumption, compared to the control food- broccoli. In the dose-response study, urinary xylose, epicatechin sulfate and 2, 6-dimethyl-2-(2-hydroxyethyl)-3,4-dihydro-2H-1-benzopyran increased as apple intake increased. Urinary xylose concentrations in a free-living cohort performed poorly at an individual level but were capable of ranking individuals in categories of intake. CONCLUSION:Urinary xylose exhibited a dose-response relationship with apple intake and performed well as a ranking biomarker in the population study. Other potential biomarkers were identified and future work will combine these with xylose in a biomarker panel which may allow for a more objective determination of individual intake.
Funding Details: European Commission Horizon 2020
Type of material: Journal Article
Publisher: Wiley
Journal: Molecular Nutrition & Food Research
Volume: 6
Issue: 11
Copyright (published version): 2020 WILEY‐VCH
Keywords: NutritionPreventionClinical ResearchApplesBiomarkersDietary assessmentFood intakeMetabolomics
DOI: 10.1002/mnfr.201901158
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Institute of Food and Health Research Collection
Agriculture and Food Science Research Collection

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