Metabolomic Based Approach to Identify Biomarkers of Apple Intake

DC FieldValueLanguage
dc.contributor.authorMcNamara, Aoife E.-
dc.contributor.authorCollins, Cassandra-
dc.contributor.authorHarsha, Pedapati S. C. Sri-
dc.contributor.authorGonzález-Peña, Diana-
dc.contributor.authorGibbons, Helena-
dc.contributor.authorMcNulty, Breige A.-
dc.contributor.authorNugent, Anne P.-
dc.contributor.authorWalton, Janette-
dc.contributor.authorFlynn, Albert-
dc.contributor.authorBrennan, Lorraine-
dc.date.accessioned2020-06-23T11:36:55Z-
dc.date.available2020-06-23T11:36:55Z-
dc.date.copyright2020 WILEY‐VCHen_US
dc.date.issued2020-06-
dc.identifier.citationMolecular Nutrition & Food Researchen_US
dc.identifier.issn1613-4125-
dc.identifier.urihttp://hdl.handle.net/10197/11395-
dc.description.abstractSCOPE:There is an increased interest in developing biomarkers of food intake to address some of the limitations associated with self-reported data. The objective was to identify biomarkers of apple intake, examine dose-response relationships and agreement with self-reported data. METHODS AND RESULTS:Metabolomic data from three studies were examined: an acute intervention, a short-term intervention and a free-living cohort study. Fasting and postprandial urine samples were collected for analysis by 1 H-NMR and LC-MS. Calibration curves were developed to determine apple intake and classify individuals into categories of intake. Multivariate analysis of data revealed that levels of multiple metabolites increased significantly post-apple consumption, compared to the control food- broccoli. In the dose-response study, urinary xylose, epicatechin sulfate and 2, 6-dimethyl-2-(2-hydroxyethyl)-3,4-dihydro-2H-1-benzopyran increased as apple intake increased. Urinary xylose concentrations in a free-living cohort performed poorly at an individual level but were capable of ranking individuals in categories of intake. CONCLUSION:Urinary xylose exhibited a dose-response relationship with apple intake and performed well as a ranking biomarker in the population study. Other potential biomarkers were identified and future work will combine these with xylose in a biomarker panel which may allow for a more objective determination of individual intake.en_US
dc.description.sponsorshipEuropean Commission Horizon 2020en_US
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsThis is the peer reviewed version of the following article: McNamara, A.E., Collins, C., Harsha, P.S.C.S., González‐Peña, D., Gibbons, H., McNulty, B.A., Nugent, A.P., Walton, J., Flynn, A. and Brennan, L. (2020), Metabolomic Based Approach to Identify Biomarkers of Apple Intake. Molecular Nutrition & Food Research. Accepted Author Manuscript., which has been published in final form at http://onlinelibrary.wiley.com/ doi:10.1002/mnfr.201901158. This article may be used for non- commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectNutritionen_US
dc.subjectPreventionen_US
dc.subjectClinical Researchen_US
dc.subjectApplesen_US
dc.subjectBiomarkersen_US
dc.subjectDietary assessmenten_US
dc.subjectFood intakeen_US
dc.subjectMetabolomicsen_US
dc.titleMetabolomic Based Approach to Identify Biomarkers of Apple Intakeen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothermaria.markiewicz-keszycka1@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume6en_US
dc.identifier.issue11en_US
dc.citation.otherArticle Number: e1901158en_US
dc.identifier.doi10.1002/mnfr.201901158-
dc.neeo.contributorMcNamara|Aoife E.|aut|-
dc.neeo.contributorCollins|Cassandra|aut|-
dc.neeo.contributorHarsha|Pedapati S. C. Sri|aut|-
dc.neeo.contributorGonzález-Peña|Diana|aut|-
dc.neeo.contributorGibbons|Helena|aut|-
dc.neeo.contributorMcNulty|Breige A.|aut|-
dc.neeo.contributorNugent|Anne P.|aut|-
dc.neeo.contributorWalton|Janette|aut|-
dc.neeo.contributorFlynn|Albert|aut|-
dc.neeo.contributorBrennan|Lorraine|aut|-
dc.date.embargo2020-10-03en_US
dc.date.updated2020-04-08T14:11:03Z-
dc.identifier.grantid647783-
item.grantfulltextembargo_20201003-
item.fulltextWith Fulltext-
Appears in Collections:Conway Institute Research Collection
Institute of Food and Health Research Collection
Agriculture and Food Science Research Collection
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