Potential of food intake biomarkers in nutrition research

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Title: Potential of food intake biomarkers in nutrition research
Authors: McNamara, Aoife E.Brennan, Lorraine
Permanent link: http://hdl.handle.net/10197/11396
Date: 26-May-2020
Online since: 2020-06-23T11:47:24Z
Abstract: The influence of dietary habits on health/disease is well-established. Accurate dietary assessment is essential to understand metabolic pathways/processes involved in this relationship. In recent years, biomarker discovery has become a major area of interest for improving dietary assessment. Well-established nutrient intake biomarkers exist, however, there is growing interest in identifying and using biomarkers for more accurate and objective measurements of food intake. Metabolomics has emerged as a key tool used for biomarker discovery, employing techniques such as nuclear magnetic resonance spectroscopy, or mass-spectrometry. To date, a number of putatively identified biomarkers were discovered for foods including meat, cruciferous vegetables and legumes. However, many of the results are associations only and lack the desired validation including dose-response studies. Food intake biomarkers can be employed to classify individuals into consumers/ non-consumers of specific foods or, into dietary patters. Food intake biomarkers can play a role in correcting self-reported measurement error, thus improving dietary intake estimates. Quanitification of food intake was previously performed for citrus (proline betaine), chicken (guanidoacetate) and grape (tartaric acid) intake. However, this area still requires more investigation and expansion to a range of foods. The present review will assess current literature of identified specific food intake biomarkers, their validation and the variety of biomarker uses. Addressing utility of biomarkers and highlighting gaps in this area is important to advance the field in the context of nutrition research.
Funding Details: European Commission Horizon 2020
Type of material: Journal Article
Publisher: Cambridge University Press
Journal: Proceedings of the Nutrition Society
Start page: 1
End page: 26
Copyright (published version): 2020 the Authors
Keywords: BiomarkersDietary assessmentFood intakeMetabolomics
DOI: 10.1017/s0029665120007053
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
Institute of Food and Health Research Collection
Agriculture and Food Science Research Collection

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