Neuropathic pain prevalence following spinal cord injury: A systematic review and meta-analysis

Files in This Item:
File Description SizeFormat 
SCI REVIEW.pdf667.62 kBAdobe PDFDownload
Title: Neuropathic pain prevalence following spinal cord injury: A systematic review and meta-analysis
Authors: Burke, DearbhlaFullen, Brona M.Stokes, DiarmuidLennon, Olive
Permanent link:
Date: Jan-2017
Online since: 2020-06-30T14:29:59Z
Abstract: Following spinal cord injury (SCI), chronic pain is a common secondary complication with neuropathic pain (NP) cited as one of the most distressing and debilitating conditions leading to poor quality of life, depression and sleep disturbances. Neuropathic pain presenting at or below the level of injury is largely refractory to current pharmacological and physical treatments. No consensus on the prevalence of NP post SCI currently exists, hence this systematic review was undertaken. The review comprised three phases: a methodological assessment of databases [PubMed, Embase, Web of Knowledge, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library and Physiotherapy Evidence Database (PEDro)] identifying potential papers and screening for inclusion criteria by two independent reviewers; data extraction; and finally rating of internal validity and strength of the evidence, using a published valid and reliable scale. Meta‐analysis estimated pooled point prevalence rates using a random effects model. In total, 17 studies involving 2529 patients were included in the review. Overall point prevalence rates for NP were established at 53% (38.58–67.47); 19% (13.26–26.39) for at‐level NP and 27% (19.89–34.61) for below‐level NP, with high heterogeneity noted (I2 = 84–93%). Prevalence rates for NP following SCI are high. Future studies should include established definitions, classification systems and assessment tools for NP at defined time points post SCI to follow the trajectory of this problem across the lifespan and include indices of sleep, mood and interference to allow for appropriate, optimal and timely NP management for each patient.
metadata.dc.description.othersponsorship: Pfizer Healthcare Ireland
Type of material: Journal Article
Publisher: Wiley
Journal: European Journal of Pain
Volume: 21
Issue: 1
Start page: 29
End page: 44
Copyright (published version): 2016 European Pain Federation
Keywords: HumansSpinal cord injuriesNeuralgiaPrevalence
DOI: 10.1002/ejp.905
Language: en
Status of Item: Peer reviewed
Appears in Collections:UCD Library Staff Research Collection
Public Health, Physiotherapy and Sports Science Research Collection

Show full item record

Citations 5

Last Week
Last month
checked on Aug 9, 2020

Page view(s)

Last Week
Last month
checked on Aug 9, 2020


checked on Aug 9, 2020

Google ScholarTM



This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.