Bionano Interactions: A Key to Mechanistic Understanding of Nanoparticle Toxicity

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Title: Bionano Interactions: A Key to Mechanistic Understanding of Nanoparticle Toxicity
Authors: Lobaskin, VladimirPower, DavidLopez, HenderPoggio, Stefano
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Date: 31-Dec-2019
Online since: 2020-07-10T11:33:32Z
Abstract: The new paradigm in the assessment of toxicity of nanomaterials relies on a mechanistic understanding of the organism’s response to an exposure to foreign materials from the initial, molecular level interactions to signaling and regulatory cascades. Here, we present a methodology to quantify the essential interactions at the bionano interface, which can be used in combination with the adverse outcome pathway analysis to build mechanism-based predictive schemes for toxicity assessments. We introduce a set of new, advanced descriptors of the nanomaterials, which refer to their ability to bind biomolecules and trigger the pathways via the molecular initiating events.
Funding Details: European Commission Horizon 2020
European Commission - Seventh Framework Programme (FP7)
Type of material: Book Chapter
Publisher: Jenny Stanford
Copyright (published version): 2020 Jenny Stanford Publishing
Keywords: Bionano interfaceMultiscale modellingCoarse-grained nanoparticles
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Language: en
Status of Item: Peer reviewed
Is part of: Puzyn T., Gajewicz A. (eds.). Computational Nanotoxicology Challenges and Perspectives
ISBN: 9789814800648
Appears in Collections:Physics Research Collection

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