Histone Deacetylase: Therapeutic Targets in Retinal Degeneration
|Title:||Histone Deacetylase: Therapeutic Targets in Retinal Degeneration||Authors:||Daly, Conor; Yin, Jun; Kennedy, Breandán||Permanent link:||http://hdl.handle.net/10197/11586||Date:||2-Oct-2015||Online since:||2020-09-22T14:45:27Z||Abstract:||Previous studies report that retinitis pigmentosa (RP) patients treated with the histone deacetylase inhibitor (HDACi) valproic acid (VPA) present with improved visual fields and delayed vision loss. However, other studies report poor efficacy and safety of HDACi in other cohorts of retinal degeneration patients. Furthermore, the molecular mechanisms by which HDACi can improve visual function is unknown, albeit HDACi can attenuate pro-apoptotic stimuli and induce expression of neuroprotective factors. Thus, further analysis of HDACi is warranted in pre-clinical models of retinal degeneration including zebrafish. Analysis of HDAC expression in developing zebrafish reveals diverse temporal expression patterns during development and maturation of visual function.||Funding Details:||Health Research Board||Type of material:||Book Chapter||Publisher:||Springer||Series/Report no.:||Advances in Experimental Medicine and Biology; 854||Copyright (published version):||2016 Springer||Keywords:||Histone deacetylase; Histone deacetylase inhibtors; Retinal degeneration; Retinitis pigmentosa; Zebrafish||DOI:||10.1007/978-3-319-17121-0_61||Language:||en||Status of Item:||Peer reviewed||Is part of:||Bowes Rickman, C., LaVail, M. M., Anderson, R. E., Grimm, C. (eds.). Retinal Degenerative Diseases: Mechanisms and Experimental Therapy||Conference Details:||The 16th International Symposium on Retinal Degeneration (RD2014), Pacific Grove, California, United States of America, 13-18 July 2014||ISBN:||978-3-319-17120-3|
|Appears in Collections:||Conway Institute Research Collection|
Biomolecular and Biomedical Science Research Collection
Show full item record
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.