Histone Deacetylase: Therapeutic Targets in Retinal Degeneration

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Title: Histone Deacetylase: Therapeutic Targets in Retinal Degeneration
Authors: Daly, ConorYin, JunKennedy, Breandán
Permanent link: http://hdl.handle.net/10197/11586
Date: 2-Oct-2015
Online since: 2020-09-22T14:45:27Z
Abstract: Previous studies report that retinitis pigmentosa (RP) patients treated with the histone deacetylase inhibitor (HDACi) valproic acid (VPA) present with improved visual fields and delayed vision loss. However, other studies report poor efficacy and safety of HDACi in other cohorts of retinal degeneration patients. Furthermore, the molecular mechanisms by which HDACi can improve visual function is unknown, albeit HDACi can attenuate pro-apoptotic stimuli and induce expression of neuroprotective factors. Thus, further analysis of HDACi is warranted in pre-clinical models of retinal degeneration including zebrafish. Analysis of HDAC expression in developing zebrafish reveals diverse temporal expression patterns during development and maturation of visual function.
Funding Details: Health Research Board
Type of material: Book Chapter
Publisher: Springer
Series/Report no.: Advances in Experimental Medicine and Biology; 854
Copyright (published version): 2016 Springer
Keywords: Histone deacetylaseHistone deacetylase inhibtorsRetinal degen­erationRetinitis pigmentosaZebrafish
DOI: 10.1007/978-3-319-17121-0_61
Language: en
Status of Item: Peer reviewed
Is part of: Bowes Rickman, C., LaVail, M. M., Anderson, R. E., Grimm, C. (eds.). Retinal Degenerative Diseases: Mechanisms and Experimental Therapy
Conference Details: The 16th International Symposium on Retinal Degeneration (RD2014), Pacific Grove, California, United States of America, 13-18 July 2014
ISBN: 978-3-319-17120-3
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection

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