Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration

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Title: Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration
Authors: Daly, ConorWard, RebeccaReynolds, AlisonGalvin, OrlaCollery, RossKennedy, Breandán
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Date: 3-May-2018
Online since: 2020-09-22T14:58:04Z
Abstract: This review discusses the therapeutic potential of brain-derived neurotrophic factor (BDNF) for retinal degeneration. BDNF, nerve growth factor (NGF), neurotrophin 3 (NT-3) and NT-4/NT-5 belong to the neurotrophin family. These neuronal modulators activate a common receptor and a specific tropomyosin-related kinase (Trk) receptor. BDNF was identified as a photoreceptor protectant in models of retinal degeneration as early as 1992. However, development of effective therapeutics that exploit this pathway has been difficult due to challenges in sustaining therapeutic levels in the retina.
Funding Details: Health Research Board
Type of material: Book Chapter
Publisher: Springer
Series/Report no.: Advances in Experimental Medicine and Biology; 1074
Copyright (published version): 2018 Springer Nature
Keywords: Brain-derived neurotrophic factorNeuroprotectionRetinal degen­erationPhotoreceptor
DOI: 10.1007/978-3-319-75402-4_57
Language: en
Status of Item: Peer reviewed
Is part of: Ash, J.D., Anderson, R.E., LaVail, M.M., Bowes Rickman, C., Hollyfield, J.G, Grimm, C. Retinal Degenerative Diseases: Mechanisms and Experimental Therapy
ISBN: 978-3-319-75401-7
Appears in Collections:Biomolecular and Biomedical Science Research Collection
Veterinary Medicine Research Collection

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