Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration
|Title:||Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration||Authors:||Daly, Conor; Ward, Rebecca; Reynolds, Alison; Galvin, Orla; Collery, Ross; Kennedy, Breandán||Permanent link:||http://hdl.handle.net/10197/11587||Date:||3-May-2018||Online since:||2020-09-22T14:58:04Z||Abstract:||This review discusses the therapeutic potential of brain-derived neurotrophic factor (BDNF) for retinal degeneration. BDNF, nerve growth factor (NGF), neurotrophin 3 (NT-3) and NT-4/NT-5 belong to the neurotrophin family. These neuronal modulators activate a common receptor and a specific tropomyosin-related kinase (Trk) receptor. BDNF was identified as a photoreceptor protectant in models of retinal degeneration as early as 1992. However, development of effective therapeutics that exploit this pathway has been difficult due to challenges in sustaining therapeutic levels in the retina.||Funding Details:||Health Research Board||Type of material:||Book Chapter||Publisher:||Springer||Series/Report no.:||Advances in Experimental Medicine and Biology; 1074||Copyright (published version):||2018 Springer Nature||Keywords:||Brain-derived neurotrophic factor; Neuroprotection; Retinal degeneration; Photoreceptor||DOI:||10.1007/978-3-319-75402-4_57||Language:||en||Status of Item:||Peer reviewed||Is part of:||Ash, J.D., Anderson, R.E., LaVail, M.M., Bowes Rickman, C., Hollyfield, J.G, Grimm, C. Retinal Degenerative Diseases: Mechanisms and Experimental Therapy||ISBN:||978-3-319-75401-7|
|Appears in Collections:||Biomolecular and Biomedical Science Research Collection|
Veterinary Medicine Research Collection
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