Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex

Title: Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex
Authors: Keane, Páraic M.Poynton, Fergus E.Hall, James P.Quinn, Susan J.
Permanent link: http://hdl.handle.net/10197/11605
Date: 13-Jul-2015
Online since: 2020-09-29T15:47:05Z
Abstract: Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ versus 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.
Funding Details: Irish Research Council
Science Foundation Ireland
Funding Details: Royal Irish Academy/Royal Society International Exchange Scheme
UK Biotechnology and Biological Sciences Research Council
College of Science, UCD
UK Science and Technology Facilities Council
Type of material: Journal Article
Publisher: Wiley
Journal: Angewandte Chemie - International Edition
Volume: 54
Issue: 29
Start page: 8364
End page: 8368
Copyright (published version): 2015 the Authors
Keywords: RutheniumGuaninePhenazinesDNAIntercalating agentsCrystallography, X-rayBase sequenceBase pairingOxidation-reductionLightModels, molecularCoordination complexes
DOI: 10.1002/anie.201502608
Language: en
Status of Item: Peer reviewed
ISSN: 1433-7851
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Chemistry Research Collection

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