Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex

DC FieldValueLanguage
dc.contributor.authorKeane, Páraic M.-
dc.contributor.authorPoynton, Fergus E.-
dc.contributor.authorHall, James P.-
dc.contributor.authorQuinn, Susan J.-
dc.date.accessioned2020-09-29T15:47:05Z-
dc.date.available2020-09-29T15:47:05Z-
dc.date.copyright2015 the Authorsen_US
dc.date.issued2015-07-13-
dc.identifier.citationAngewandte Chemie - International Editionen_US
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10197/11605-
dc.description.abstractSmall changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ versus 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.en_US
dc.description.sponsorshipIrish Research Councilen_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectRutheniumen_US
dc.subjectGuanineen_US
dc.subjectPhenazinesen_US
dc.subjectDNAen_US
dc.subjectIntercalating agentsen_US
dc.subjectCrystallography, X-rayen_US
dc.subjectBase sequenceen_US
dc.subjectBase pairingen_US
dc.subjectOxidation-reductionen_US
dc.subjectLighten_US
dc.subjectModels, molecularen_US
dc.subjectCoordination complexesen_US
dc.titleReversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complexen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothersusan.quinn@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume54en_US
dc.identifier.issue29en_US
dc.identifier.startpage8364en_US
dc.identifier.endpage8368en_US
dc.identifier.doi10.1002/anie.201502608-
dc.neeo.contributorKeane|Páraic M.|aut|-
dc.neeo.contributorPoynton|Fergus E.|aut|-
dc.neeo.contributorHall|James P.|aut|-
dc.neeo.contributorQuinn|Susan J.|aut|-
dc.description.othersponsorshipRoyal Irish Academy/Royal Society International Exchange Schemeen_US
dc.description.othersponsorshipUK Biotechnology and Biological Sciences Research Councilen_US
dc.description.othersponsorshipCollege of Science, UCDen_US
dc.description.othersponsorshipUK Science and Technology Facilities Councilen_US
dc.date.updated2020-09-21T14:36:15Z-
item.fulltextWith Fulltext-
item.grantfulltextopen-
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