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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex
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| Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Com.pdf | 2.31 MB | Adobe PDF | Download |
| Title: | Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex | Authors: | Keane, Páraic M.; Poynton, Fergus E.; Hall, James P.; Quinn, Susan J. | Permanent link: | http://hdl.handle.net/10197/11605 | Date: | 13-Jul-2015 | Online since: | 2020-09-29T15:47:05Z | Abstract: | Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ versus 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides. | Funding Details: | Irish Research Council Science Foundation Ireland |
Funding Details: | Royal Irish Academy/Royal Society International Exchange Scheme UK Biotechnology and Biological Sciences Research Council College of Science, UCD UK Science and Technology Facilities Council |
Type of material: | Journal Article | Publisher: | Wiley | Journal: | Angewandte Chemie - International Edition | Volume: | 54 | Issue: | 29 | Start page: | 8364 | End page: | 8368 | Copyright (published version): | 2015 the Authors | Keywords: | Ruthenium; Guanine; Phenazines; DNA; Intercalating agents; Crystallography, X-ray; Base sequence; Base pairing; Oxidation-reduction; Light; Models, molecular; Coordination complexes | DOI: | 10.1002/anie.201502608 | Language: | en | Status of Item: | Peer reviewed | ISSN: | 1433-7851 | This item is made available under a Creative Commons License: | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ |
| Appears in Collections: | Chemistry Research Collection |
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