Enantiomeric conformation controls rate and yield of photoinduced electron transfer in DNA sensitized by Ru(II) dipyridophenazine complexes

Files in This Item:
File Description SizeFormat 
Keane_Ru_enantiomer_JPCL_final.pdf441.13 kBAdobe PDFDownload
Title: Enantiomeric conformation controls rate and yield of photoinduced electron transfer in DNA sensitized by Ru(II) dipyridophenazine complexes
Authors: Keane, Páraic M.Poynton, Fergus E.Hall, James P.Quinn, Susan J.et al.
Permanent link: http://hdl.handle.net/10197/11607
Date: 5-Feb-2015
Online since: 2020-09-29T16:03:42Z
Abstract: Photosensitized oxidation of guanine is an important route to DNA damage. Ruthenium polypyridyls are very useful photosensitizers, as their reactivity and DNA-binding properties are readily tunable. Here we show a strong difference in the reactivity of the two enantiomers of [Ru(TAP)2(dppz)]2+, by using time-resolved visible and IR spectroscopy. This reveals that the photosensitized one-electron oxidation of guanine in three oligonucleotide sequences proceeds with similar rates and yields for bound Δ-[Ru(TAP)2(dppz)]2+, whereas those for the λ enantiomer are very sensitive to base sequence. It is proposed that these differences are due to preferences of each enantiomer for different binding sites in the duplex.
Funding Details: Irish Research Council
Science Foundation Ireland
University College Dublin
metadata.dc.description.othersponsorship: Royal Irish Academy/Royal Society exchange program
UK Biotechnology and Biological Sciences Research Council
Type of material: Journal Article
Publisher: American Chemical Society
Journal: Journal of Physical Chemistry Letters
Volume: 6
Issue: 4
Start page: 734
End page: 738
Copyright (published version): 2015 American Chemical Society
Keywords: RutheniumDNAElectron transportStereoisomerismElectrons
DOI: 10.1021/jz502743q
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

Show full item record

Page view(s)

176
Last Week
49
Last month
checked on Oct 26, 2020

Download(s)

34
checked on Oct 26, 2020

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.