Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy

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Title: Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy
Authors: Keane, Páraic M.Baptista, Frederico R.Gurung, Sarah P.Devereux, Stephen J.Quinn, Susan J.et al.
Permanent link: http://hdl.handle.net/10197/11613
Date: 4-May-2016
Online since: 2020-09-30T16:53:50Z
Abstract: UV-generated excited states of cytosine (C) nucleobases are precursors to mutagenic photoproduct formation. The i-motif formed from C-rich sequences is known to exhibit high yields of long-lived excited states following UV absorption. Here the excited states of several i-motif structures have been characterized following 267 nm laser excitation using time-resolved infrared spectroscopy (TRIR). All structures possess a long-lived excited state of ∼300 ps and notably in some cases decays greater than 1 ns are observed. These unusually long-lived lifetimes are attributed to the interdigitated DNA structure which prevents direct base stacking overlap.
Funding Details: University College Dublin
metadata.dc.description.othersponsorship: Biotechnology and Biological Sciences Research Council
Royal Irish Academy/Royal Society
Type of material: Journal Article
Publisher: Wiley
Journal: ChemPhysChem
Volume: 17
Issue: 9
Start page: 1281
End page: 1287
Copyright (published version): 2016 Wiley
Keywords: NucleotidesInfrared spectrophotometryUltraviolet spectrophotometryCircular dichroismKinetics
DOI: 10.1002/cphc.201501183
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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