Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy

Files in This Item:
File Description SizeFormat 
2016 ChemPhysChem_imotif_as accepted.pdf1.33 MBAdobe PDFDownload
Title: Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy
Authors: Keane, Páraic M.Baptista, Frederico R.Gurung, Sarah P.Devereux, Stephen J.Quinn, Susan J.et al.
Permanent link: http://hdl.handle.net/10197/11613
Date: 4-May-2016
Online since: 2020-09-30T16:53:50Z
Abstract: UV-generated excited states of cytosine (C) nucleobases are precursors to mutagenic photoproduct formation. The i-motif formed from C-rich sequences is known to exhibit high yields of long-lived excited states following UV absorption. Here the excited states of several i-motif structures have been characterized following 267 nm laser excitation using time-resolved infrared spectroscopy (TRIR). All structures possess a long-lived excited state of ∼300 ps and notably in some cases decays greater than 1 ns are observed. These unusually long-lived lifetimes are attributed to the interdigitated DNA structure which prevents direct base stacking overlap.
Funding Details: University College Dublin
metadata.dc.description.othersponsorship: Biotechnology and Biological Sciences Research Council
Royal Irish Academy/Royal Society
Type of material: Journal Article
Publisher: Wiley
Journal: ChemPhysChem
Volume: 17
Issue: 9
Start page: 1281
End page: 1287
Copyright (published version): 2016 Wiley
Keywords: NucleotidesInfrared spectrophotometryUltraviolet spectrophotometryCircular dichroismKinetics
DOI: 10.1002/cphc.201501183
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

Show full item record

Page view(s)

172
Last Week
50
Last month
checked on Oct 25, 2020

Download(s)

15
checked on Oct 25, 2020

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.