Multiple myeloma in an Amur tiger (Panthera tigris altaica)

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Title: Multiple myeloma in an Amur tiger (Panthera tigris altaica)
Authors: Lee, Alison MarieGuppy, NaomiBainbridge, JohnJahns, Hanne
Permanent link: http://hdl.handle.net/10197/11674
Date: 8-Nov-2017
Online since: 2020-11-05T09:57:33Z
Abstract: The Amur tiger (Panthera tigris altaica) is an endangered tiger subspecies. An adult zoo-bred female was found collapsed, and died despite supportive treatment. Hematology and biochemistry showed pancytopenia and hyperglobulinemia, and serum protein electrophoresis revealed a monoclonal band in the β-globulin region. Necropsy demonstrated hemoabdomen, multifocal lytic bone marrow lesions, splenomegaly, and hemorrhagic hepatic nodules, with left medial lobe rupture. There were mutifocal hemorrhages in the subcutis, lung, epicardium, and intestinal mucosa. Histopathology demonstrated plasmacytoid cells infiltrating the bone marrow, liver and spleen, and circulating within blood vessels. On immunohistochemistry, cell infiltrates of the three tissues were positive for λ light chains, bone marrow infiltrates were positive for MUM-1 and bone marrow and spleen infiltrates were positive for CD20. These findings indicate that this animal died of hemoabdomen subsequent to multiple myeloma. This is the first time this disease has been reported in a tiger.
Funding Details: Health Service Executive
Type of material: Journal Article
Publisher: Faculty of Veterinary Medicine, University of Tripoli
Journal: Open Veterinary Journal
Volume: 7
Issue: 4
Start page: 300
End page: 305
Copyright (published version): 2017 Faculty of Veterinary Medicine, University of Tripoli
Keywords: Amur tigerImmunohistochemistryMultiple myelomaPanthera tigris altaicaSerum protein electrophoresisFelineCanineCats
DOI: 10.4314/ovj.v7i4.2
Language: en
Status of Item: Peer reviewed
ISSN: 2226-4485
Appears in Collections:Veterinary Medicine Research Collection

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