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miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy
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| Title: | miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy | Authors: | Bielefeld, Pascal; Mooney, Catherine; Henshall, David C.; Fitzsimons, Carlos P | Permanent link: | http://hdl.handle.net/10197/11759 | Date: | 9-Nov-2017 | Online since: | 2020-11-30T15:47:08Z | Abstract: | Hippocampal neural stem/progenitor cells (NSPCs) proliferate and differentiate to generate new neurons across the life span of most mammals, including humans. This process takes place within a characteristic local microenvironment where NSPCs interact with a variety of other cell types and encounter systemic regulatory factors. Within this microenvironment, cell intrinsic gene expression programs are modulated by cell extrinsic signals through complex interactions, in many cases involving short non-coding RNA molecules, such as miRNAs. Here we review the regulation of gene expression in NSPCs by miRNAs and its possible implications for epilepsy, which has been linked to alterations in adult hippocampal neurogenesis. | Type of material: | Journal Article | Publisher: | IOS Press | Journal: | Brain Plasticity | Volume: | 3 | Issue: | 1 | Start page: | 43 | End page: | 59 | Copyright (published version): | 2017 IOS Press and the Authors | Keywords: | miRNA; Epilepsy; Neurodegenerative; Genetics; Neural stem cell; Neurogenic niche; Adult hippocampal neurogenesis | DOI: | 10.3233/BPL-160036 | Language: | en | Status of Item: | Peer reviewed | ISSN: | 2213-6304 | This item is made available under a Creative Commons License: | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ |
| Appears in Collections: | Computer Science Research Collection |
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