De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP

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Title: De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP
Authors: Sheedy, CarolineMooney, ClaireJimenez-Mateos, Eva M.Mooney, Catherine
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Date: 15-Dec-2014
Online since: 2020-12-01T15:50:05Z
Abstract: The C/EBP homologous protein CHOP is normally present at low levels in cells but increases rapidly after insults such as DNA damage or endoplasmatic reticulum stress where it contributes to cellular homeostasis and apoptosis. By forming heterodimers with other transcription factors, CHOP can either act as a dominant-negative regulator of gene expression or to induce the expression of target genes. Recent work demonstrated that seizure-induced hippocampal damage is significantly worse in mice lacking CHOP and these animals go on to develop an aggravated epileptic phenotype. To identify novel CHOP-controlled target genes which potentially influence the epileptic phenotype, we performed a bioinformatics analysis of tissue microarrays from chop-deficient mice after prolonged seizures. GO analysis revealed genes associated with biological membranes were prominent among those in the chop-deficient array dataset and we identified myelin-associated genes to be particularly de-repressed. These data suggest CHOP might act as an inhibitor of myelin-associated processes in the brain and could be targeted to influence axonal regeneration or reorganisation.
Funding Details: Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: E-Century Publishing
Journal: International Journal of Physiology, Pathophysiology and Pharmacology
Volume: 6
Issue: 4
Start page: 185
End page: 198
Copyright (published version): © 2014 E-Century Publishing Corporation.
Keywords: CHOPEpilepsymRNAMicroarrayMyelin basic proteinStatus epilepticus
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Language: en
Status of Item: Peer reviewed
ISSN: 1944-8171
This item is made available under a Creative Commons License:
Appears in Collections:Computer Science Research Collection

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