Extraction and yield optimisation of fucose, glucans and associated antioxidant activities from laminaria digitata by applying response surface methodology to high intensity ultrasound-assisted extraction

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dc.contributor.authorGarcía-Vaquero, Marco-
dc.contributor.authorRajauria, Gaurav-
dc.contributor.authorTiwari, Brijesh K.-
dc.contributor.authorSweeney, Torres-
dc.contributor.authorO'Doherty, John V.-
dc.date.accessioned2021-01-18T16:33:22Z-
dc.date.available2021-01-18T16:33:22Z-
dc.date.copyright2018 the Authorsen_US
dc.date.issued2018-07-30-
dc.identifier.citationMarine Drugsen_US
dc.identifier.issn1660-3397-
dc.identifier.urihttp://hdl.handle.net/10197/11847-
dc.description.abstractThe objectives of this study were to employ response surface methodology (RSM) to investigate and optimize the effect of ultrasound-assisted extraction (UAE) variables, temperature, time and amplitude on the yields of polysaccharides (fucose and total glucans) and antioxidant activities (ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-picryl-hydrazyl radical scavenging activity (DPPH)) from Laminaria digitata, and to explore the suitability of applying the optimum UAE conditions for L. digitata to other brown macroalgae (L. hyperborea and Ascophyllum nodosum). The RSM with three-factor, four-level Box-Behnken Design (BBD) was used to study and optimize the extraction variables. A second order polynomial model fitted well to the experimental data with R2 values of 0.79, 0.66, 0.64, 0.73 for fucose, total glucans, FRAP and DPPH, respectively. The UAE parameters studied had a significant influence on the levels of fucose, FRAP and DPPH. The optimised UAE conditions (temperature = 76 ◦C, time = 10 min and amplitude = 100%) achieved yields of fucose (1060.7 ± 70.6 mg/100 g dried seaweed (ds)), total glucans (968.6 ± 13.3 mg/100 g ds), FRAP (8.7 ± 0.5 µM trolox/mg freeze-dried extract (fde)) and DPPH (11.0 ± 0.2%) in L. digitata. Polysaccharide rich extracts were also attained from L. hyperborea and A. nodosum with variable results when utilizing the optimum UAE conditions for L. digitata.en_US
dc.description.sponsorshipScience Foundation Irelanden_US
dc.format.mediumElectronic-
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectLaminariaen_US
dc.subjectSeaweeden_US
dc.subjectPhenolsen_US
dc.subjectGlucansen_US
dc.subjectFucoseen_US
dc.subjectPolysaccharidesen_US
dc.subjectFree radical scavengersen_US
dc.subjectChemical fractionationen_US
dc.subjectUltrasonic wavesen_US
dc.titleExtraction and yield optimisation of fucose, glucans and associated antioxidant activities from laminaria digitata by applying response surface methodology to high intensity ultrasound-assisted extractionen_US
dc.typeJournal Articleen_US
dc.internal.authorcontactothermarco.garciavaquero@ucd.ieen_US
dc.statusPeer revieweden_US
dc.identifier.volume16en_US
dc.identifier.issue8en_US
dc.citation.otherArticle Number: 257en_US
dc.identifier.doi10.3390/md16080257-
dc.neeo.contributorGarcía-Vaquero|Marco|aut|-
dc.neeo.contributorRajauria|Gaurav|aut|-
dc.neeo.contributorTiwari|Brijesh K.|aut|-
dc.neeo.contributorSweeney|Torres|aut|-
dc.neeo.contributorO'Doherty|John V.|aut|-
dc.date.updated2020-04-17T16:27:19Z-
dc.identifier.grantid14/IA/2548-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/en_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
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