Fibril size-dependent control of polar ordering in type I collagen membranes
|Title:||Fibril size-dependent control of polar ordering in type I collagen membranes||Authors:||Zhang, Fengyuan; Rodriguez, Brian J.; Sawamura, Steven; Paukshto, Michael V.||Permanent link:||http://hdl.handle.net/10197/11997||Date:||Oct-2020||Online since:||2021-03-02T15:31:57Z||Abstract:||The most abundant protein in the human body, collagen, is widely used in tissue culture and engineering applications, spanning from substrate functionalization to fibrillar architectures and three-dimensional constructs. Collagen piezoelectricity provides an opportunity to exploit electromechanical coupling in these applications, wherein an applied mechanical stress generates charge, which might influence ion screening, protein absorption, and cell response. In type I collagen, the polarization direction follows the fibril orientation. Thus, control of fibril orientation and size in a collagen film or membrane may provide control of the polarization, enabling the creation of regions of uniform polarization direction. Here, aligned substrate-supported type I collagen membranes having fibril sizes from ∼100-500 nm are deposited using different osmotic concentrations (90, 190, and 290 mOsm/kg, from low to high ionic strength) to investigate the correlation between fibril size and piezoelectric properties. Lateral piezoresponse force microscopy is used to show that regions of uniform polarization orientation, as determined through 2D correlation analysis, decrease with increasing fibril size.||Funding Details:||European Commission Horizon 2020||Funding Details:||China Scholarship Council||Type of material:||Journal Article||Publisher:||IEEE||Journal:||IEEE Transactions on Dielectrics and Electrical Insulation||Volume:||27||Issue:||5||Start page:||1662||End page:||1667||Copyright (published version):||2020 IEEE||Keywords:||Correlation; Piezoelectric polarization; Force; Surface topography||DOI:||10.1109/TDEI.2020.008936||Language:||en||Status of Item:||Peer reviewed||ISSN:||1070-9878||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by-nc-nd/3.0/ie/|
|Appears in Collections:||Conway Institute Research Collection|
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