Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties

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Title: Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties
Authors: Rosales, IvonneSalazar, LauraLuna, DanielRodriguez, Brian J.et al.
Permanent link: http://hdl.handle.net/10197/12004
Date: Jan-2021
Online since: 2021-03-02T17:33:40Z
Abstract: Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases; 2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field.
Funding Details: Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica
Type of material: Journal Article
Publisher: Scientific Research Publishing
Journal: American Journal of Molecular Biology
Volume: 11
Start page: 1
End page: 14
Copyright (published version): 2021 the Authors and Scientific Research Publishing
Keywords: AmyloidNeurodegenerative disordersSelf-assemblyPiezoelectricity
DOI: 10.4236/ajmb.2021.111001
Language: en
Status of Item: Peer reviewed
ISSN: 2161-6620
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by/3.0/ie/
Appears in Collections:Conway Institute Research Collection
Physics Research Collection

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