Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties
|Title:||Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties||Authors:||Rosales, Ivonne; Salazar, Laura; Luna, Daniel; Rodriguez, Brian J.; et al.||Permanent link:||http://hdl.handle.net/10197/12004||Date:||Jan-2021||Online since:||2021-03-02T17:33:40Z||Abstract:||Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases; 2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field.||Funding Details:||Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica||Type of material:||Journal Article||Publisher:||Scientific Research Publishing||Journal:||American Journal of Molecular Biology||Volume:||11||Start page:||1||End page:||14||Copyright (published version):||2021 the Authors and Scientific Research Publishing||Keywords:||Amyloid; Neurodegenerative disorders; Self-assembly; Piezoelectricity||DOI:||10.4236/ajmb.2021.111001||Language:||en||Status of Item:||Peer reviewed||ISSN:||2161-6620||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by/3.0/ie/|
|Appears in Collections:||Conway Institute Research Collection|
Physics Research Collection
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