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Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties
Date Issued
2021-01
Date Available
2021-03-02T17:33:40Z
Abstract
Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases; 2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field.
Other Sponsorship
Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica
Type of Material
Journal Article
Publisher
Scientific Research Publishing
Journal
American Journal of Molecular Biology
Volume
11
Start Page
1
End Page
14
Copyright (Published Version)
2021 the Authors and Scientific Research Publishing
Language
English
Status of Item
Peer reviewed
ISSN
2161-6620
This item is made available under a Creative Commons License
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