Per Artursson's Major Contributions to the Caco-2 Cell Literature in Pharmaceutical Sciences

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Title: Per Artursson's Major Contributions to the Caco-2 Cell Literature in Pharmaceutical Sciences
Authors: Brayden, David James
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Date: Jan-2021
Online since: 2021-03-08T13:21:16Z
Abstract: This edition of the Journal of Pharmaceutical Sciences is dedicated to the wonderful career of Per Artursson from the University of Uppsala. My Commentary focusses on Per's major contributions to the Caco-2 cell literature over the past 30 years. Two especially influential papers have been cited more than 1000 times out of a total citation count of almost 30,000 and a h-index of 93 (Google Scholar), making Per one of the most cited and influential Pharmaceutical scientists of his generation. The Caco-2 field to which Per contributed so many advances has informed the community on key areas including predictive drug fluxes across the intestine, metabolism by intestinal epithelia, the role of transporters during flux, enantiomer-selective flux, excipient interaction with tight junctions, and nanoparticle uptake by enterocytes. In this pioneering work, Per has been careful to emphasise that Caco-2 monolayers have limitations and are a model of the human small intestine where observations must be backed up with in vitro tissue and in vivo work. Throughout, he has paid great attention to detail in methodology, as reflected by co-authorship of two Nature Protocols on Caco-2 assays. The article briefly assesses some of the most important milestones in Per's published Caco-2 research.
Type of material: Journal Article
Publisher: Elsevier
Journal: Journal of Pharmaceutical Sciences
Volume: 110
Issue: 1
Start page: 12
End page: 16
Copyright (published version): 2020 American Pharmacists Association
Keywords: Caco-2 cellsIntestinal permeabilityEpithelial transportCarrier-mediated fluxEpithelial tight junctionsM-like cells
DOI: 10.1016/j.xphs.2020.08.016
Language: en
Status of Item: Peer reviewed
ISSN: 0022-3549
This item is made available under a Creative Commons License:
Appears in Collections:Conway Institute Research Collection
Veterinary Medicine Research Collection

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