Current understanding of biological identity at the nanoscale and future prospects

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Title: Current understanding of biological identity at the nanoscale and future prospects
Authors: Dawson, Kenneth A.Yan, Yan
Permanent link: http://hdl.handle.net/10197/12173
Date: Mar-2021
Online since: 2021-05-18T15:36:46Z
Abstract: Nanoscale objects are processed by living organisms using highly evolved and sophisticated endogenous cellular networks, specifically designed to manage objects of this size. While these processes potentially allow nanostructures unique access to and control over key biological machineries, they are also highly protected by cell or host defence mechanisms at all levels. A thorough understanding of bionanoscale recognition events, including the molecules involved in the cell recognition machinery, the nature of information transferred during recognition processes and the coupled downstream cellular processing, would allow us to achieve a qualitatively novel form of biological control and advanced therapeutics. Here we discuss evolving fundamental microscopic and mechanistic understanding of biological nanoscale recognition. We consider the interface between a nanostructure and a target cell membrane, outlining the categories of nanostructure properties that are recognized, and the associated nanoscale signal transduction and cellular programming mechanisms that constitute biological recognition.
Funding Details: Science Foundation Ireland
Funding Details: Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment
Type of material: Journal Article
Publisher: Springer Nature
Journal: Nature Nanotechnology
Volume: 16
Issue: 3
Start page: 229
End page: 242
Copyright (published version): 2021 Springer Nature
Keywords: NanobiotechnologyNanoparticlesBionanoscale recognition
DOI: 10.1038/s41565-021-00860-0
Language: en
Status of Item: Peer reviewed
ISSN: 1748-3387
This item is made available under a Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
Appears in Collections:Centre for Bionano Interactions (CBNI) Research Collection
Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection
Chemistry Research Collection

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